The MOST-Monitor for Oxygenation of Surface and Tissue

Transmittance pulse oximetry is currently the preferred method of noninvasive oxgenative monitoring. However, this type of monitoring is limited with regards to peripheral probe placement, creating an inability to measure deep-tissue oxygenation to the level desired. Recently reflective methods have been applied to pulse oimetry; however, the reflected signal isdifficult to measure and interpret. The reflective studies performed to date utilize individual probe placement and measurements schemes. We propose an alternative approach invoking multiple probes fabricated to incorporate deep tissue oxygenation characterization in conjunction with surface assessment. A volumetric profile will be established to formulate a more complete representation of systemic oxygenation - a profile with increased resolution and sensitivity. Associated experimental data integrated with theoretical analysis will assist in the formulation of a coherent mathematical model. Time resolved spectroscopy will be investigated using pulse sequencing as opposed to individual narrow pulses. This approach will augment experimental tissue diffusion investigation. The Phase I study will produce the sensor system design to best detect surface and deep tissue oxygenation noninvasively.