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Multistage Dielectrophoretic Sample Preparation System

Award Information
Agency: Department of Homeland Security
Branch: N/A
Contract: D11PC20135
Agency Tracking Number: 11110044
Amount: $99,992.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: H-SB011.1-002
Solicitation Number: N/A
Solicitation Year: 2011
Award Year: 2011
Award Start Date (Proposal Award Date): 2011-05-15
Award End Date (Contract End Date): 2011-11-30
Small Business Information
20600 Gramercy Place, Bldg. 100
Torrance, CA 90501-1821
United States
DUNS: 153865951
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Gregory Zeltser
Business Contact
 Gordon Drew
Phone: (310) 320-3088
Research Institution

High-fidelity biomolecular analysis techniques, such as PCR, DNA sequencing, or ELISA, rely heavily on adequate sample
preprocessing. To achieve maximum performance from these sensitive analytical techniques, the DHS needs novel methods for flowthrough
systems that prepare and concentrate biological materials from environmental samples. Physical Optics Corporation (POC)
proposes to develop a Multistage Dielectrophoretic Sample Preparation (MDSP) system, based on a size-exclusion filtering method
combined with a multistage electrodeless dielectrophoretic separation technique. Separation of biological material is followed by biomaterial
purification, elution, concentration, and collection. The MDSP system will be composed of a reusable microfluidic chip,
microfluidic platform, and readout unit. The innovations in the MDSP system enable it to perform biological material separation into
four classes: bacterial cells and spores, viral particles, DNAs/RNAs, and proteins/polypeptides. In Phase I, POC will demonstrate the
feasibility of the MDSP system by developing a benchtop prototype capable of separating, purifying, concentrating, and collecting the
four individual classes of biological material from a mixture containing mineral debris in less than 15 minutes. In Phase II, POC plans
to develop a fully functional MDSP system prototype capable of processing biological material from environmental samples, such as
soil, that can be integrated into an automated detection system.

* Information listed above is at the time of submission. *

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