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ULTRA HIGH RESOLUTION SQUID MAGNETOMETERS FOR BIOLOGICAL

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R42GM054963-02A1
Agency Tracking Number: 2R42GM5496302A1
Amount: $330,868.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: 001
Solicitation Number: N/A
Timeline
Solicitation Year: 1999
Award Year: 2000
Award Start Date (Proposal Award Date): 2000-02-01
Award End Date (Contract End Date): 2002-01-31
Small Business Information
175 Clearbrook Rd
Elmsford, NY 10523
United States
DUNS: 103734869
HUBZone Owned: Yes
Woman Owned: Yes
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Masoud  Radparvar
 (914) 592-1190
 masoud@hypres.com
Business Contact
 Masoud  Radparvar
Phone: (914) 592-1190
Email: masoud@hypres.com
Research Institution
N/A
Abstract

DESCRIPTION (Adapted from Applicant's Abstract): The objective of the proposed research is to develop ultra-high resolution, thin film low-temperature superconductivity (LTS) SQUID magnetometers (UHRSM) with integrated pickup-loops. The UHRSM will be optimized for imaging of the magnetic fields produced by action currents, injury and developmental currents, remanent magnetization, and magnetic susceptibility in isolated living tissue and small experimental animal preparations. During Phase I, the applicants innovation in SQUID design and fabrication already produced a reliable, simple to operate, inexpensive SQUID sensor with integrated pick-up coils, whose flux noise was comparable to the best commercially available SQUID sensors. The integration of the SQUID sensor into a cryogenic system resulted in a prototype instrument currently incorporated into an active research program at Vanderbilt University. Their present design allows a window-to-SQUID spacing of less than 20mm. The prototype proposed to be developed under the Phase II project will be an inexpensive, modular, customizable, bench-top LTS SQUID instrument for biological research with spatial resolution below 100mm and field sensitivities on the order of 1pT/(square root Hz). The proposed instrument will be capable of making measurements that are impossible with any other electric or magnetic instrument, and should lead to new insights into cellular biology and electro- and magnetophysiology. The existing expertise will be exploited further to develop and improve SQUID sensors for general and custom biomagnetic applications which require higher-sensitivity SQUID magnetometers and gradiometers but lower spatial resolution. PROPOSED COMMERCIAL APPLICATION: The cryogenic technology, the expertise in SQUID design, and they STTR grant would allow us to target SQUID microscopes with spatial resolutions below 100 microm with sensitivities around 1 pT/Hz-1/2. The LTS SQUIDs enables new measurements with a higher bandwidth, a higher spatial resolution and a much faster scanning rate due to a superior signal to noise ratio. The market for such an instrument is not enormous, but we are convinced to sell 5-10 systems mainly used in research per year. However, should the instrument be widely accepted, for example, as quality control instrument in the immunodiagnostic industry or as instrument to perform NDE on electronic components, we could sell tens of systems per year.

* Information listed above is at the time of submission. *

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