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Novel Strip Test for Circulating Hormones

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 32958
Amount: $69,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1996
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
P.O. Box 1306
Ann Arbor, MI 48106
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Judith L. Erb
 (313) 995-9338
Business Contact
Phone: () -
Research Institution
N/A
Abstract

Concentrations of most circulating hormones and their metabolites are too low for existing test strip technologies to measure. Laboratory measurements are based upon immunological binding of these hormones. Color tests utilizing colloidal gold or enzyme mediated color changes have been linked to immunological binding and applied to hormones to yield non-quantitative yes or no tests. These methods cannot provide semi-quantitative determination of the hormone concentration without introducing procedural complicaitons. Innovation Associates proposes to develop test strips for homones utilizing an innovative technology which will permit the binding between antibody and antigen to be translated into a visually apparent color response. Strips will not utilize enzymes or colloidal gold. Semiquantification of analyte will be achieved by comparing the location of the color change on the strip to a concentration scale int he manner of a thermometer. Feasibility of the technology will be demonstrated in Phase I be applying it to the development of test strips for the metabolites of the female reproductive hormone estradiol and progesterone in urine. The method will be rapid (10 minutes or less), simple (requiring only exposure of the strip to a diluted sample), and strips will be more stable than tests employing enzymes.

* Information listed above is at the time of submission. *

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