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Oligonucleotide Enzyme Surrogate (OnES)

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: FA8650-08-M-6915
Agency Tracking Number: C081-108-0102
Amount: $99,957.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD08-108
Solicitation Number: 2008.1
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-05-28
Award End Date (Contract End Date): 2008-11-28
Small Business Information
One Tech Plaza 2113 Wells Branch Parkway, Sui
Austin, TX 78728
United States
DUNS: 084994735
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Jean Bishop
 Principal Investigator
 (512) 617-3387
Business Contact
 Austin Sequeira
Title: Director
Phone: (512) 782-8204
Research Institution

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tendency to produce an immune response. In order to avoid this issue, Accacia International will manipulate DNA oligonucleotides using a novel and innovative selection method. DNA aptamers will be selected through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method to accomplish the task of creating an enzyme surrogate.

* Information listed above is at the time of submission. *

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