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Orally Administered Bioadherent Sustained Release Microencapsulated Vaccines

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 28325
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
7610 Eastmark Drive, Suite 105
College Station, TX 77840
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Cynthia L. Sheffield
 (409) 693-0017
Business Contact
Phone: () -
Research Institution

Parenteral vaccines have many limitations which pose problems for both military and civilian vaccination programs. Parenteral vaccines must be administered by trained personnel, a booster is generally required for maximum protection, they usually contain a single immunogen and require refrigeration. Bioadherent sustained release microencapsulated (BSRM) vaccines for oral administration will eliminate many of the parenteral vaccine limitations. The proposed work will utilize recombinant Fasciola hepatica proteins, to form a BSRM staphlococcal enterotoxin vaccine for oral administration. The Fasciola recombinant proteins were selected because of their natural long term, single dose protection without requiring administration by trained personnel. Further, a multivalent vaccine could be designed by loading SBRMs containing different immunogens into an outer capsule (i.e., gelatine) for administration. In Phase I, the in vivo gastrointestinal retention time, diffusion kinetics and serum antibody titers for a BSRM staphlococcus enterotoxin vaccine will be evaluated. In Phase II, the porosity, bioadherence and final packaging of the SBRM will be optimized.

* Information listed above is at the time of submission. *

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