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Pharmaceutical Development for Alcoholism Treatment

Description:

The topic focuses on applied and, where appropriate, clinical research on pharmacologic agents for use in the treatment or medical management of alcoholism, disorders resulting from alcoholism, the improvement and refinement of drugs currently available for therapeutic purposes, or drugs suitable for use in basic research studies on alcohol addiction. Areas that may be of interest to small businesses include, but are not limited to:

A. Development of agents to attenuate drinking behavior, e.g., drugs to curb craving

B. Development of aversive agents such as disulfiram that can attenuate drinking behavior

C. Development of agents to treat acute alcohol withdrawal

D. Development of drugs that are capable of improving or reversing alcohol-induced cognitive impairments

E. Development of agents to induce sobriety in intoxicated individuals (i.e., amethystic agents)

F. Development of agents to treat associated psychiatric disorders and/or drug abuse, and to diminish drinking

G. Development of improved methods of drug delivery for the treatment of alcoholism. The systems developed must be capable of maintaining therapeutic drug levels for extended periods of time to alleviate compliance problems.

H. Development of drugs for the treatment of alcoholic hepatitis, cirrhosis, pancreatitis, cardiomyopathy, or other alcohol-induced tissue damage

I. Research on the pharmacodynamics and pharmacokinetics of concurrent ethanol and other drug use.

For clinical questions, contact:

Joanne B. Fertig, Ph.D.

301-443-0635

Email: Joanne.Fertig@nih.gov

For pre-clinical questions, contact:

Mark Egli, Ph.D. (Neuroscience and behavior)

301-594-6382

Email: Mark.Egli@nih.gov

Svetlana Radaeva, Ph.D. (Organ damage)

301-433-1189

Email: sr252a@nih.gov

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