PREPARATION OF MONOCLONAL ANTIBODIES TO PLANT-DERIVED OLIGO- AND POLYSACCHARIDES

Award Information

Agency: Department of Energy

Branch: N/A

Contract: N/A

Agency Tracking Number: 6982

Amount: $50,000.00

Phase: Phase I

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1987

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

Complex Carbohydrate Corp

2351 College Station Rd #512

Athens, GA 30605

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: DR MICHAEL G HAHN
Phone: (404) 546-7797

Business Contact

Phone: () -

Research Institution

N/A

Abstract

THE PURPOSE OF THIS RESEARCH PROJECT IS TO GENERATE MONOCLONAL ANTIBODIES THAT RECOGNIZE DEFINED EPITOPES ON OLIGO- AND POLYSACCHARIDES OF PLANT ORIGIN. SUCH ANTIBODIESWILL BE USEFUL FOR PURIFYING PLANT-DERIVED OLIGO- AND POLYSACCHARIDES, PROVIDING STRUCTURAL INFORMATION ABOUT THE CARBOHYDRATES TO WHICH THE ANTIBODIES BIND, AND DETERMINING THE TISSUE AND CELLULAR DISTRIBUTION OF THE CARBOHYDRATES. THE FEASIBILITY OF GENERATING SUCH MONOCLONAL ANTIBODIES WILL BE EXAMINED IN PHASE I. HYBRIDOMA CELL LINES THAT SECRETE MONOCLONAL ANTIBODIES TO RHAMNOGALACTURONAN-I, A PLANT CELL-WALL DERIVED POLYSACCHARIDE, WILL BE GENERATED. THE COMPLETE STRUCTURE OF THE EPITOPE RECOGNIZED BY AT LEAST ONE OF THE ANTIBODIES WILL BE DETERMINED. THESE STUDIES WILL BE EXTENDED IN PHASE II TO INCLUDE CHARACTERIZATION OF EPITOPES RECOGNIZED BY OTHER ANTI-RHAMNOGALACTURONAN-I ANTIBODIES AND GENERATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO ADDITIONAL PLANT-DERIVED OLIGO- AND POLYSACCHARIDES.

* Information listed above is at the time of submission. *

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PREPARATION OF MONOCLONAL ANTIBODIES TO PLANT-DERIVED OLIGO- AND POLYSACCHARIDES