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Preservation Matrix for Improved Biological Specimen Storage and Recovery

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D13PC00040
Agency Tracking Number: D12B-001-0019
Amount: $100,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: ST12B-001
Solicitation Number: 2012.B
Timeline
Solicitation Year: 2012
Award Year: 2013
Award Start Date (Proposal Award Date): 2013-01-28
Award End Date (Contract End Date): 2013-07-27
Small Business Information
1 Riverside Circle Suite 400
Roanoke, VA -
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Ben Lepene
 Director of R&D
 (434) 220-2509
 butlerb@lunainnovations.com
Business Contact
 Shirley Evans
Title: Sr. Contract Administrator
Phone: (540) 961-6724
Email: submissions302@lunainnovations.com
Research Institution
 North Carolina State University
 Sam Hudson
 
3116 College of Textiles Box 8301, Room 3116
Raleigh, NC 27695-
United States

 (919) 515-6545
 Nonprofit College or University
Abstract

Luna Innovations will determine the feasibility of modifying our novel bio-encapsulation technology for enhanced recovery of viral and bacterial targets from swab-like biospecimens. In the proposed Phase I, Luna will work with Dr. Hudson (North Carolina State Univiersity, College of Textiles) in order to modify our encapsulation process for integration with non-woven materials for swab collection. The swab material will be composed of FDA-approved reversible-biopolymers allowing for easy dissolution of the preservation matrix for increased recovery of specimen analytes. Luna's preservation technology has been successfully applied to protein and whole cell encapsulation, providing significant improvements in storage life-time and temperature stability reducing the need for cold chain requirements while improving the accuracy of pathogen detection. In order to demonstrate enhanced recovery of analytes, various pathogens (bacterial and viral) will be tested for viability and detection rate as a function of preservation time and temperature. The compatibility with standard downstream analyses will also be determined. Phase II will focus on increasing preservation time (transport and storage) while also maximizing recovery efficiency of biospecimen analytes and optimizing integration with downstream analytical detection methods.

* Information listed above is at the time of submission. *

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