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ULTRA-HIGH RESOLUTION ACOUSTIC MICROSCOPY

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA094389-01
Agency Tracking Number: CA094389
Amount: $336,986.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
J AND W MEDICAL, INC. 56 PATRICK RD
WESTPORT, CT 06880
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BAHRAM JADIDIAN
 (203) 226-0810
 B.JADIDIAN@JWMED.COM
Business Contact
Phone: (203) 226-0810
Research Institution
N/A
Abstract

A novel, broadband scanning acoustic microscope (SAM) for in vivo imaging and characterization of micro-cellular biological tissue structures is proposed. It will operate at a frequency of 4.0 GHz, which offers a resolution of less than 0.4 microns, orders of magnitude less than that commercially available for medical diagnostic and non-destructive testing applications. The transducer will be fabricated by two methods: (1) utilizing a sol-gel process to grow the element as a single crystal, and (2) forming the element with pulsed laser deposition (PLD). Each pixel of an acoustic C-Scan image will provide information about the absorption, elastic properties and density of tissue cells, which may improve the visualization and clinical assessment of consistent patterns of cellular malignancy. The C-Scan image will be formed with a novel technique that utilizes a piezoelectric actuator for precise and reliable micro-stepping in a raster format for data acquisition and image presentation. A feasibility assessment of the clinical utility of the proposed design will be carried out at Thomas Jefferson University Hospital (Philadelphia., PA). Acoustic images will be taken of a wide variety of normal tissue specimens and the measured acoustic features compared with those obtained with standard transmissive and reflective optical techniques for tissue characterization. Proposed Commercial Application: A 4.0 GHz acoustic microscope offer significant benefits for both medical and material science applications. If successful, Layered Manufacturing Inc. is prepared to license the technology to all interested ultrasound system companies.

* Information listed above is at the time of submission. *

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