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Vaccine for Mycobacterium Tuberculosis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI36799-01A1,
Agency Tracking Number: 29095
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1124 Columbia, Suite 464
Seattle, WA 98104
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Steven Reed
 () -
Business Contact
Phone: () -
Research Institution

The goal of this investigation is to develop the invasin gene as a vaccine against M. tuberculosishuman host. Up to the present time, the only known and generally accepted vaccine-BCG-is a living athas shown variable efficacy in the countries where it has been used. Although efforts by other invesof obtaining non-viable vaccine have not proved successful, the concept of a new candidate vaccine cpriority. The cloned invasin, in combination with selected adjuvants will be evaluated for protectioand disease in a mouse model. The designed proposal will investigate the immunoprotective potentialThe investigators will i) immunize mice using the invasin protein, ii) characterize the immune resptuberculosis to the invasin protein, and iii) produce monoclonal antibodies and mouse T cell lines ainvasin protein. Parts i and ii will be addressed in the first six months of the grant period. Partsubsequent years.

* Information listed above is at the time of submission. *

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