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Vapor-based Manufacturing Multifunctional Coatings

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL084842-01A1
Agency Tracking Number: HL084842
Amount: $159,323.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2006
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (734) 763-7543
Business Contact
Phone: (734) 995-9089
Research Institution

DESCRIPTION (provided by applicant): We propose a new manufacturing process for multifunctional coatings of biomedical implants. Towards this goal, polymer coatings applied by chemical vapor deposition (CVD) are exceptional candidates for the coating of implanted biomedical devices as indicated by their use in FDA approved drug-eluting stint (Cypher stint, J&J) uses a vapor-deposited polymer (parylene). These commercially available coatings are however chemically limited and are not compatible with a multifunctional coating design. In contrast, we have recently developed biomedical coatings based on a novel class of vapor-deposited polymers: functionalized poly-p-xylylenes, which can be multi-functional and custom-tailored. Ultimately, Phase II activities of this STTR application will result in a commercial manufacturing process for multi-functional coatings that will utilize a computer-controlled reaction system for CVD co- polymerization of multiple, modular combinable building blocks. However, several specific design questions with respect to the manufacturing process remain unclear and will be addressed in Phase I as follows: Aim #1: Establish missing specifications for the manufacturing process: 1. Is the sublimation temperature an appropriate control parameter to ensure manufacturing of multi- functional coatings with defined polymer composition while avoiding layering effects? 2. Will a variation of monomer ratios result in defined polymer ratios? 3. What is the initial biocompatibility of the CVD-based co-polymers? Aim #2: Demonstrate dual drug immobilization onto multi-functional coatings. 1. Can multifunctional coatings support the dual immobilization of two different biomolecules? 2. After dual immobilization, is the biological activity of both biomolecules maintained? A process will be developed to apply multi-function coatings to medical devices. Such coatings will improve the safety and function of implanted medical devices.

* Information listed above is at the time of submission. *

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