HHS Solicitations Schedule


NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Solicitation Agency Program Due Date Close Date
Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 09/05/2021
Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 09/05/2021
SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 04/05/2021
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) HHS SBIR Multiple 01/13/2021
Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 01/05/2021
Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 01/05/2021
Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 01/05/2021
Radiological/Nuclear Medical Countermeasure Product Development Program (SBIR) (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 01/05/2021
Department of Health and Human Services Part 1. Overview Information HHS SBIR Multiple 01/05/2021
BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)(R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 01/05/2021
Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44- Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 01/05/2021
Competing Renewal Awards of SBIR Phase IIB Grants for Brain and Behavior Tools (R44-Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44- Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R41/R42- Clinical Trial Optional) HHS STTR Multiple 01/05/2021
Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
NIBIB Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) HHS SBIR Multiple 01/05/2021
NINDS Exploratory Clinical Trials for Small Business (R42 Clinical Trial Required) HHS STTR Multiple 01/05/2021
NINDS Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) HHS SBIR Multiple 01/05/2021
Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R41/R42Clinical Trial Not Allowed). HHS STTR Multiple 01/05/2021
Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed). HHS SBIR Multiple 01/05/2021
Innovative Molecular Analysis Technology Development for Cancer Research and Clinical Care (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 01/05/2021
NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional) HHS SBIR Multiple 01/05/2021
Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (UT2 Clinical Trial Optional) HHS STTR Multiple 12/04/2020
Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (U44- Clinical Trial Optional) HHS SBIR Multiple 12/04/2020
BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required) HHS SBIR Multiple 10/21/2020
Translational Neural Devices (U44 Clinical Trial Required) HHS SBIR Multiple 10/21/2020
CREATE Bio Development Track: Nonclinical and Early-Phase Clinical Development for Biologics (U44 Clinical Trial Optional) HHS SBIR Multiple 09/07/2020
CREATE Bio Optimization Track for Biologics (SBIR-U44) HHS SBIR Multiple 09/07/2020
Analytical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional) HHS SBIR Multiple 09/07/2020
CREATE Bio Development Track: Nonclinical and Early-Phase Clinical Development for Biologics (U44 Clinical Trial Optional) HHS SBIR Multiple 09/07/2020
Clinical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional) HHS SBIR Multiple 09/07/2020
Technologies for Healthy Independent Living for Heart, Lung, Blood and Sleep Disorders (R43- Clinical Trial Not Allowed) HHS SBIR Multiple 06/10/2020
Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) HHS SBIR Multiple 05/07/2020
Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44) HHS SBIR Multiple 05/07/2020
Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42 Clinical Trial Optional) HHS STTR Multiple 04/06/2020
Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42) HHS STTR Multiple 04/05/2020
Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 04/05/2020
Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44) HHS SBIR Multiple 04/05/2020
Assistive Technology for Persons with Alzheimer's Disease and Related Dementias and Their Caregivers (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 01/08/2020
Assistive Technology for Persons with Alzheimer's Disease and Related Dementias and Their Caregivers (R41/R42 Clinical Trial Optional) HHS STTR Multiple 01/08/2020
Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 01/05/2020
Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 01/05/2020
Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 01/05/2020
Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R41/R42 Clinical Trial Optional) HHS STTR Multiple 01/05/2020
Kidney Precision Medicine Project- Technology Development and Validation (R41/R42) HHS STTR Multiple 01/05/2020
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42) HHS STTR Multiple 01/05/2020
Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R43) HHS SBIR Multiple 01/05/2020
Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R41) HHS STTR Multiple 01/05/2020
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44) HHS SBIR Multiple 01/05/2020
Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42) HHS STTR Multiple 01/05/2020
Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44) HHS SBIR Multiple 01/05/2020
Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R43/R44) HHS SBIR Multiple 01/05/2020
Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R41/R42) HHS STTR Multiple 01/05/2020
Kidney Precision Medicine Project- Technology Development and Validation (R43/R44) HHS SBIR Multiple 01/05/2020
Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional) HHS STTR Multiple 09/05/2019
T1 Translational Research on Aging: Small Business Innovation Awards (R43/R44) HHS SBIR Multiple 09/05/2019
Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 09/05/2019
T2 Translational Research on Aging: Small Business Innovation Awards (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 09/05/2019
T2 Translational Research on Aging: Small Business Innovation Awards (R43/R44) HHS SBIR Multiple 09/05/2019
Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42) HHS STTR Multiple 09/05/2019
T1 Translational Research on Aging: Small Business Innovation Awards (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 09/05/2019
Tools for Clinical Care and Management of Alzheimer’s Disease (AD) and Its Comorbidities (R41/R42) HHS STTR Multiple 09/05/2019
Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44) HHS SBIR Multiple 09/05/2019
Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (STTR) (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 09/05/2019
Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (SBIR) (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 09/05/2019
NIDDK Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) HHS SBIR Multiple 09/05/2019
Platform Delivery Technologies for Nucleic Acid Therapeutics (R43/R44) HHS SBIR Multiple 09/05/2019
Platform Delivery Technologies for Nucleic Acid Therapeutics (R41/R42) HHS STTR Multiple 09/05/2019
NIDDK Exploratory Clinical Trials for Small Business (R44) HHS SBIR Multiple 09/05/2019
Tools for Clinical Care and Management of Alzheimer’s Disease (AD) and its Comorbidities (R43/R44) HHS SBIR Multiple 09/05/2019
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) HHS SBIR Multiple 05/13/2019
PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) HHS SBIR Multiple 04/05/2019
New Technologies for the Glycosciences (R43/R44) HHS SBIR Multiple 04/05/2019
New Technologies for the Glycosciences (R41/42) HHS STTR Multiple 04/05/2019
Small Business Alzheimer's Disease Research (R41/R42) HHS STTR Multiple 04/05/2019
Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R43/R44) HHS SBIR Multiple 04/05/2019
Small Business Alzheimer's Disease Research (R43/R44) HHS SBIR Multiple 04/05/2019
Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R41/R42) HHS STTR Multiple 04/05/2019
Products to Support Applied Research Towards Zero Suicide Healthcare Systems (R43/R44) HHS SBIR Multiple 04/05/2019
PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) HHS STTR Multiple 04/05/2019
PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) HHS STTR Multiple 04/05/2019
PHS 2018-02 Omnibus Solicitation of the NIH for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) HHS SBIR Multiple 04/05/2019
Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R43/R44) HHS SBIR Multiple 04/05/2019
Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42) HHS STTR Multiple 04/05/2019
Tools for Cell Line Identification (SBIR [R43/R44]) HHS SBIR Multiple 04/05/2019
Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 04/05/2019
The Use of mRNA for an HIV Envelope Vaccine (R41/R42) HHS STTR Multiple 04/05/2019
The Use of mRNA for an HIV Envelope Vaccine (R43/R44) HHS SBIR Multiple 04/05/2019
Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed) HHS SBIR Multiple 04/05/2019
Methods Development in Natural Products Chemistry (R43/R44) HHS SBIR Multiple 04/05/2019
Methods Development in Natural Products Chemistry (R41/R42) HHS STTR Multiple 04/05/2019
Products to Support Applied Research Towards Zero Suicide Healthcare Systems (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 04/05/2019
Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Not Allowed) HHS STTR Multiple 04/05/2019
Wearable Alcohol Biosensors SBIR (R43/R44 Clinical Trial Optional) HHS SBIR Multiple 04/04/2019
Wearable Alcohol Biosensors SBIR (R43/R44) HHS SBIR Multiple 04/04/2019
Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R43/R44) HHS SBIR Multiple 09/07/2018
Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R41/R42) HHS STTR Multiple 09/07/2018
HHS STTR PAR-15-185 HHS STTR Multiple 09/05/2018
SBIR Technology Transfer (R43/R44) HHS SBIR Multiple 09/05/2018
HHS SBIR PAR-15-186 HHS SBIR Multiple 09/05/2018
SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional) HHS SBIR 08/15/2018 08/15/2018
Safe and Effective Devices for Use In Neonatal, Perinatal and Pediatric Care Settings (R43/R44 Clinical Trial Optional) HHS SBIR 08/01/2018 08/01/2018
Small Market Awards: SBIR Phase IIB Competing Renewals for Heart, Lung, Blood, and Sleep Technologies with Small Commercial Markets (R44) HHS SBIR Multiple 06/20/2018

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government