Recyclable Magnetic Co C Hybrid ROMP Reagents Scavengers and Ligands

DESCRIPTION provided by applicant This Fast Track Small Business Technology Transfer study between Materia Inc in Pasadena CA and the University of Kansas intends to build upon successes of our current Phase II Fast Track STTR grant R GM which ends on March Preliminary results serve as a solid foundation for this Fast Track submission entitled andquot Development of Recyclable Magnetic Co C Hybrid ROMP Ligands Reagents Scavengersandquot This proposal aims to develop optimize and scale up recyclable magnetic Co C hybrid ROMP ligands reagents scavengers and streamline the process for their commercialization More specifically Phase I will focus on two key areas namely the development and generation of multi gram quantities of five recyclable magnetic high load Co C hybrid ROMP ligands reagents scavengers utilizing surface initiated ROM polymerization where the Phase I Milestone Goal is the synthesis and multi gram scale up of five reagents namely Co C OTPP Co C OOAS Co C OPC Co C OMam and Co C OPy and utilization of magnetic Co C hybrid ROMP reagents in synthetic transformations for the facilitated synthesis of small molecules applications in parallel synthesis and sequestration protocols The Phase II goals are threefold and include the development of an array of high load ROMP derived oligomeric ligands catalysts reagents and scavengers immobilized on Co C magnetic NPs utilizing surface initiated ROM polymerization process optimization for scale up of recyclable magnetic high load Co C ROMP hybrid reagents and utilization of these hybrid magnetic reagents in synthetic transformations for the facilitated synthesis of small molecules applications in parallel synthesis and automated technologies We are well positioned to meet the challenges of this proposal with expertise in the use of ROMP technologies for the production of soluble and Si immobilized reagents KU and Materia Inc a Co C nanoparticle technology collaboration with Professor Oliver Reiser at the University of Regensburg Dr Robert Grass at the Swiss Federal Institute of Technology in Zurich ETHZ Switzerland and the use of ROMP reagents for production of chemical libraries within the Center for Chemical Methodologies and Library Development at The University of Kansas KU CMLD These efforts are augmented with the core technologies and expertise within Materia Inc for process optimization and scale up synthesis Moreover associations within the KU CMLD and pharmaceutical companies will allow for beta testing of the reagents within drug discovery and commodity chemical platforms If successful these magnetic reagents will represent a new green technology for commercialization that will aid in streamlining the synthesis of chemical entities in a sustainable manner PUBLIC HEALTH RELEVANCE This project entitled Recyclable Magnetic Co C Hybrid ROMP Ligands Reagent Scavengers aims for the production and commercialization of high load recyclable magnetic Co C Hybrid ROMP ligands reagents and scavengers for the facilitated synthesis of small molecules applications in parallel synthesis and automated technologies to aid in modern drug discovery efforts