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High speed Intraoperative Assessment of Breast Tumor Margin using MarginPAT

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA200006-01A1
Agency Tracking Number: R41CA200006
Amount: $275,943.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: O
Solicitation Number: PA15-270
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-08-25
Award End Date (Contract End Date): 2017-08-24
Small Business Information
Lafayette, IN 47906-9063
United States
DUNS: 079182447
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (617) 353-1276
Business Contact
Phone: (317) 429-7387
Research Institution
United States

 Nonprofit College or University

After a breast conserving therapy histology is often performed to check whether
the excised tumor specimen is surrounded by a sufficient amount of normal tissue
If a positive margin is identified then a second operation will be performed
Currently the re operation rate is which raises a need for intraoperative
detection of residual cancers The current intraoperative tools for margin
assessment are time consuming and lack sufficient tumor specificity Multiple
emerging optical technologies improved the sensitivity and specificity but still
suffered from a long procedure time We propose a multi modal spectroscopic
photoacoustic ultrasound imaging system to differentiate cancer and normal tissue
in a resected breast tissue Providing both chemical content and mechanical
property information this system named MarginPAT is able to measure map
tissue components including blood fat fibrosis tissue and breast lesion Based
on a compact Raman laser and a high speed scanning chamber the proposed
MarginPAT system is able to scan cm tissue area per min which is faster than
the frozen section analysis gold standard for intraoperative assessment by one
order of magnitude Such capacities allow dimensional assessment of margin
status in the entire excised tissue with andgt sensitivity and specificity As breast conserving surgery or lumpectomy is well accepted for the breast cancer
treatment a highly sensitive tool is critically needed for intraoperative margin
assessment We propose a multi modal photoacoustic ultrasound imaging system for
high speed high sensitivity intraoperative margin assessment

* Information listed above is at the time of submission. *

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