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Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41EY026826-01A1
Agency Tracking Number: R41EY026826
Amount: $225,635.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N
Solicitation Number: PA15-270
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-30
Award End Date (Contract End Date): 2019-09-29
Small Business Information
Rockville, MD 20850-5451
United States
DUNS: 801231494
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (301) 294-7003
Business Contact
Phone: (301) 704-7360
Research Institution

In the United States retinal disease is the most common cause of visual impairment with age related
macular degeneration AMD and diabetic retinopathy DR being the most common retinal diseases For each
of the above conditions high resolution and three dimensional D imaging of the retina retinal vasculature
choroid and or retinal pigment epithelium RPE is critical for diagnosis and research into the disease as well as
for monitoring response to treatment Pathology to any of these structures can lead to vision loss since the
health and function of the retina is dependent upon proper functioning of all of these components An inexpensive
and simple method to image all of these fundus structures at high resolution and in three dimensions would
dramatically improve patient care and medical research
The goal of this project is to apply Fresnel Incoherent Correlation Holography FINCH to human fundus
imaging FINCH is a self referenced low coherence holographic technique that can create super resolved D
holographic images from any light source including fluorescent or reflected light from the human eye fundus A
FINCH based fundus imaging system would improve resolution and D imaging capability of fundus photography
and all types of fluorescence angiography for retinal vasculature while also potentially providing depth and
thickness maps of retinal layers in a mode similar to Optical Coherence Tomography All this could be done in a
single instrument with operational modes identical to fluorescence angiography and fundus photography For
this Phase I research program the well understood design principles of FINCH will be used to adapt a standard
commercial fundus camera for FINCH imaging The prototype FINCH fundus camera will be used to image
lifelike eye tissue phantoms as well as human subjects in order to establish its efficacy in fundus imaging The
long term goal of this research is the construction of inexpensive turn key FINCH camera units specially designed
to interface with commercial fundus cameras to enable greater availability of high resolution D fundus imaging
in clinical care and medical research Project Narrative
High resolution three dimensional fast imaging of the human retina and ocular fundus would improve diagnostic
and treatment capabilities in the practice of ophthalmology as well as basic eye research The proposed project
will develop an additional holographic camera as an add on to existing fundus photography and fluorescence
angiography imaging systems transforming them from low resolution D systems into very high resolution
imaging systems with D vision that can better see the relationships between all the structures in the eye all
without changing the operation of the fundus imaging system The basis for the project resides on this
laboratory s successful development over the years of a simple fluorescence microscope based upon a laser
less holographic principle that effortlessly creates D super resolution images

* Information listed above is at the time of submission. *

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