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Automated Point-of-Care Identification of Innocent Still's Murmur in Children

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL131081-01A1
Agency Tracking Number: R41HL131081
Amount: $177,688.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PAR13-091
Solicitation Year: 2013
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-06
Award End Date (Contract End Date): 2018-08-31
Small Business Information
Dayton, MD 21036-1142
United States
DUNS: 079727453
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (202) 476-1201
Business Contact
Phone: (202) 355-3560
Research Institution

The overall goal of the proposed research and technology transfer effort is to develop a low cost
point of care mobile device based technology for automated identification of Stillandapos s murmur
the most common innocent benign and harmless heart murmur of childhood This novel
technology could reduce the current rate of over a million children unnecessarily referred to
pediatric cardiologists by general physicians each year in the United States Investigators from
Auscultech Dx a startup company and Childrenandapos s National Medical Center will collaborate to
begin converting the academic patent pending research into a commercial product through this
STTR initiative The three specific aims of the project are to refine and test thoroughly the
algorithm for identifying Stillandapos s murmur improve and test smartphone stethoscope and
integrate hardware and software components to develop a fully integrated prototype These aims
will lead to the development of a fully integrated prototype that records and discriminates
pediatric heart murmurs in this Phase I feasibility study In Phase II we will continue with
prototype improvements and conduct a clinical trial with general physicians and pursue
regulatory and marketing approvals The successful completion of this feasibility study in Phase
I and subsequent clinical testing in Phase II will result in a validated device for identifying Stillandapos s
murmur in an office setting Significant reduction in the number of unnecessary referrals will
save the healthcare system hundreds of millions of dollars annually allow pediatric cardiologists
to focus on patients with serious conditions and save children and families from the
unnecessary anxiety inconvenience and expense of seeing a cardiologist PROJECT NARRATIVE
Over a million children are referred to pediatric cardiologists by general physicians for the
evaluation of Stillandapos s murmur a normal and harmless heart murmur This project will develop a
novel mobile technology for automated recognition of this murmur and reducing the current
rate of such unnecessary referrals

* Information listed above is at the time of submission. *

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