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Development of a Behavioral Activation Mobile App for depressed Latinos

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41MD010491-01
Agency Tracking Number: R41MD010491
Amount: $224,977.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 102
Solicitation Number: MD15-008
Timeline
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-01
Award End Date (Contract End Date): 2018-08-31
Small Business Information
2 WISCONSIN CIR STE 700
Chevy Chase, MD 20815-7007
United States
DUNS: 078733869
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MATTHEW CARPENTER
 (843) 876-2436
 carpente@musc.edu
Business Contact
 JACOB KUSTANOWITZ
Phone: (202) 670-8020
Email: jack@mountainpasstech.com
Research Institution
N/A
Abstract

DESCRIPTION provided by applicant Treatment for depression is a core health disparity for Latinos in the U S Although U S Latinos are more likely than non Hispanic Whites to experience depression Alegria et al U S Latinos are less than half as likely as Whites to receive evidence based care for depression Lagomasino et al Latinos with elevated depressive symptoms are most likely to report such symptoms to primary care physicians PCPs Lewis Fernandez et al who in turn typically prescribe antidepressant medication and rarely recommend psychotherapy This limited recommendation of psychotherapy is problematic because as compared to Whites Latinos are less likely to take antidepressant medication when prescribed Miranda andamp Cooper and prefer psychotherapy as compared to medication for the treatment of depression Cooper et al Thus in order to reduce the depression treatment disparity for Latinos the dissemination of evidence based therapies for depression via PCPs must be improved Mobile technologies including smartphones and mobile applications apps are widely used by Latinos in the U S and offer an ideal vehicle for meeting widespread treatment needs As behavior therapies have demonstrated efficacy for the treatment of depression among Latino patients e g Collado et al these therapies are natural fits when selecting a treatment to adapt for delivery via a
mobile app and recommendation by a PCP One behavior therapy that is especially appropriate for this group is brief Behavioral Activation BA Lejuez et al Collado et al Considering that Latinos in the U S are a heterogenous group brief BA is an ideal fit because it is idiographic affords the accommodation of personal values on an individual basis and can be delivered in Spanish Moreover brief BA is appropriate for delivery via a mobile app and for recommendation by a PCP because it is simple straightforward and evidence based In this Phase I STTR we will leverage our previous research in order to develop test and refine a Spanish language mobile app version of brief BA Apptivaci n Conductual in the service of increasing access to evidence based depression treatment for Latinos We will conduct a small scale randomized clinical trial with U S Latino adults with limited English proficiency and elevated depressive symptoms referred from local PCPs who will be randomized to receive either Apptivaci n Conductual or a CBT based Spanish language mobile app iCouch CBT Key outcomes include treatment feasibility acceptability adherence and change in depressive symptoms associated with Apptivaci n Conductual as compared to iCouch CBT Via product development testing and refinement consistent with the STTR Phase I mechanism we expect to create a marketable product for which we will pursue larger scale clinical testing in an STTR Phase II study

PUBLIC HEALTH RELEVANCE
Depression treatment is a core health disparity for Latinos in the U S as U S Latinos are more likely than non Hispanic Whites to experience depression but are less than half as likely as Whites to receive evidence based care for depressive symptomatology Mobile technologies offer an ideal strategy for meeting the widespread depression treatment needs of U S Latinos as recent U S population level data suggests that Latinos adopt smartphones at a rate higher than any other demographic group The purpose of the proposed project is to develop test and refine a Spanish language mobile application version of brief Behavioral Activation an idiographic straightforward empirically supported treatment for elevated depressive symptoms for referral by primary care physicians in the service of increasing access to evidence based treatment for depression for Latinos

* Information listed above is at the time of submission. *

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