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Bio-Mathematical Models of Aggregated Tissues & Organ Properties

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-16-C-0081
Agency Tracking Number: H16A-001-0005
Amount: $149,976.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHP16A-001
Solicitation Number: 2016.0
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-19
Award End Date (Contract End Date): 2017-04-18
Small Business Information
11010 Lake Grove Blvd.
Morrisville, NC 27560
United States
DUNS: 079910976
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Nicholas Laucis MD
 (314) 609-1588
Business Contact
 Christine Heneghan
Phone: (919) 523-6019
Research Institution
 The University of North Carolina at Chapel Hill
 M. Gregory Forest Ph.D.
Phillips Hall Room 316A CB#3250 Chapel Hill NC 27599-3250 \N
Chapel Hill, NC 27599
United States

 (919) 962-9606
 Nonprofit College or University

BioMojo LLC and the Departments of Mathematics and Biomedical Engineering at the University of North Carolina Chapel Hill, will develop a preliminary bio mathematical model framework to represent how human tissues interact and behave at their boundaries. Tissue interaction properties (e.g. tensile, shear, friction, and so forth) of connective, epithelial, muscular, and nervous tissue including sub-components of each of these broad categories lack fidelity in current simulation systems. We propose a multiscale network approach, coarse-graining the cellular structure in a tissue sample based on their microstructure obtained through 3D tissue imaging analysis. We will first identify tissue types, boundaries between tissue types, and the microstructure features of the full sample. After clearly demarcating boundaries between any adjacent tissue types, we will then triangulate each domain based on the knowledge we would have gained from studying that type of tissue using continuum models. The long term goal of this effort is to create integrated multi-scale biophysical mathematical tissue models to represent the interactions of aggregated tissues and organs. The models will be demonstrated in an interactive software prototype in Phase II and will ultimately be used for virtual reality, manikin-based, and/or hybrid medical simulation systems.

* Information listed above is at the time of submission. *

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