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Bio-inspired Macromolecules Containing Atomically Precise Catalytic Active Sites

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-SC0015741
Agency Tracking Number: 0000223745
Amount: $149,829.48
Phase: Phase I
Program: STTR
Solicitation Topic Code: 09
Solicitation Number: DE-FOA-0001417
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-06-13
Award End Date (Contract End Date): 2017-03-12
Small Business Information
200 Yellow Place
Rockledge, FL 32955-5327
United States
DUNS: 175302579
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Ted Amundsen
 (321) 631-3550
Business Contact
 Michael Rizzo
Title: Mr.
Phone: (321) 631-3550
Research Institution
 Temple University
3340 North Broad Street 3340 North Broad Street
Philadelphia, PA 19140-5102
United States

 (215) 707-7547
 Nonprofit College or University

High selectivity in chemical reactions is the key to reducing costs, energy consumption and
emissions in chemical processing. More selective and active catalysts will reduce the need for
recovering unreacted chemicals for recycle and removing byproducts. Reducing the burden on
separation processes will greatly reduce the energy required for chemical production.
We propose to design macromolecular catalysts that resemble clamshells to act as highly
selective C-H activation catalysts. These macro molecules will create complex, chiral pockets to
bind metal ions, react with oxidants or molecular oxygen and react selectively with C-H bonds in
a variety of hydrocarbon compounds.
Prof. Schafmeister and his group at Temple University have already developed large, robust,
abiotic macromolecules that resemble clamshells with programmable three-dimensional shapes.
Mainstream Engineering will evaluate the catalytic activity of these materials when exposed to a
panel of substrates to confirm the production of desired products as well as observe off-target
catalytic activity that could lead to new applications of these molecules. Mainstream will also
conduct a detailed commercialization analysis of all potential chemical pathways to ensure that
the most lucrative products and catalysts are pursued in Phase II.
The commercial applications of these catalysts are immense and include pharmaceuticals,
agrochemicals and personal care products. The public will benefit from lower cost goods as a
result of more efficiently manufacturing processes. The public will also benefit from the reduced
emissions of processes made more efficient by these catalysts.
Key Words – Catalyst, biomimetic, selectivity, asymmetric
Summary for Members of Congress: New catalysts are needed to improve selectivity and yield
during chemical processing. We are developing new materials capable of performing much more
selective chemistry than previously possible with conventional catalysts.

* Information listed above is at the time of submission. *

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