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Innovative concept for detection and identification of biological toxins

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: HDTRA1-16-P-0039
Agency Tracking Number: C152-005-0156
Amount: $147,976.50
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD152-005
Solicitation Number: 2015.2
Timeline
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-14
Award End Date (Contract End Date): 2017-03-13
Small Business Information
85 Bolton Street
Cambridge, MA 02140
United States
DUNS: 027868040
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 William Rodriguez
 (617) 336-3299
 wrodriguez@daktaridx.com
Business Contact
 Matthew Gorman
Phone: (617) 336-3299
Email: mgorman@daktaridx.com
Research Institution
N/A
Abstract

The focus of this SBIR proposal is to demonstrate rapid, multiplexed detection of acute bacterial and viral pathogens of global importance on asingle test platform. Daktaris microfluidic immunoassay platform, under development since 2009 for HIV and hepatitis C (HCV) applications, iscapable of femtomolar detection of bacterial and viral antigens consistent with needs for infectious disease diagnosis with high clinical sensitivity.Moreover, by integrating sample preparation, detection, and information connectivity, seamless sample-to-answer results can be obtained by aminimally trained user starting from a single fingerstick drop of whole blood in less than 30 minutes, and transmitted worldwide for immediateaction. The Daktari platform has been demonstrated and validated for HIV applications in rural fishing villages in Kasensero, Uganda andunder-resourced clinics in Nairobi, Kenya. Here, we propose to extend Daktaris platform beyond fingerstick detection of HIV and HCV viral load,to create a single, multiplexed cartridge for the detection of active infection with four key pathogens: Yersinia pestis, Brucella spp., Dengue virus,and Chikungunya virus. In addition to their potential use as bioweapons, these four pathogens occur naturally, yet front-line clinicians and firstresponders lack useful, rapid diagnostic tools that can be deployed widely for routine outbreak surveillance in populations at risk.

* Information listed above is at the time of submission. *

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