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Innovative concept for detection and identification of biological toxins

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: FA4819-16-C-0001
Agency Tracking Number: C2-0421
Amount: $1,040,562.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: CBD14-101
Solicitation Number: 2014.1
Solicitation Year: 2014
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-01-29
Award End Date (Contract End Date): 2018-05-01
Small Business Information
419 Lafayette Street
New York, NY 10003
United States
DUNS: 145785528
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Lori Lepak
 (718) 484-7033
Business Contact
 Nicole Avallone
Phone: (718) 484-7033
Research Institution

The objective of the proposed Phase II project is to develop a hand-held, rapid plasmonic biosensor -- a detector based upon surfaceplasmon resonances (SPR) that incorporates a new class of supercharged proteins that functionalize a low-cost, disposable plasmonicchip. Each protein is designed to bind to a pre-determined toxin with high specificity. Upon successful binding, the protein superfoldsrelative to a typical immunoassay system, causing a correspondingly large change in the index of refraction immediately adjacent to thesurface of the plasmonic chip, that subsequently changes the transmission of light through the chip. In Phase I, we designed,synthesized, and characterized a supercharged protein that binds the model toxin heme. This protein demonstrated a large bindinginducedrefractive index change that is calculated to correspond to a 1001000 fold improvement in SPR signal relative to commerciallyavailable systems. In Phase II, these results will be extended to proteins that selectively bind to ricin, anthrax and sarin. Also in PhaseII, the hand-held optical module and plasmonic chip will be improved to increase performance and reduce cost. This project will beperformed by Phoebus Optoelectronics, in collaboration with the NSF IUCRC Center for Metamaterials at CUNY and Lockheed Martin.

* Information listed above is at the time of submission. *

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