Wearable Neurophysiological Monitoring Device for Circadian Rhythm Assessment and Intervention

This Phase I STTR project will develop a platform to demonstrate high-quality, multi-modal acquisition of neurophysiological signals, including EEG, heart rate/blood oxygenation via photoplethysmography (PPG), electrodermal (EDA) activity, temperature plus environmental factors such as ambient light and sound in a simple, wearable headband. The hardware will be coupled with the development of a clinical study protocol, involving PTSD cases, to correlate the data from the hardware with known hormonal circadian markers to build a dataset for the development of automated analysis algorithms. Success in Phase I will directly to lead to Phase II efforts to conduct the clinical evaluation of the device, refine the hardware, develop the signal processing algorithms for automated circadian rhythm analysis and interface the system with interventional stimuli.