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A Novel System for Reducing Radiation Dose of CT Perfusion

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41EB024438-01A1
Agency Tracking Number: R41EB024438
Amount: $265,898.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 100
Solicitation Number: PA16-303
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-01
Award End Date (Contract End Date): 2018-07-31
Small Business Information
Calabasas, CA 91302-1736
United States
DUNS: 080086210
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (310) 948-3390
Business Contact
Phone: (310) 948-3390
Research Institution
LOS ANGELES, CA 90033-1036
United States

 Nonprofit College or University

Project Summary Abstract
X ray computed tomography CT has been increasingly used in medical diagnosis currently reaching more
than million CT scans every year in the US The increasing use of CT has sparked concern over the effects
of radiation dose on patients It is estimated that every CT scans will cause one future cancer i e
cases of future cancers from million CT scans every year CT brain perfusion CTP is a widely used
imaging technique for the evaluation of hemodynamic changes in stroke and cerebrovascular disorders
However CTP involves high radiation dose for patients as the CTP scan is repeated on the order of times
at the same anatomical location in order to capture the full passage of the contrast bolus This has been
raised as a major concern by the FDA especially when multiple successive CTPs are performed on the same
patient e g to monitor reperfusion following recanalization Several techniques have been applied for radiation
dose reduction in CTP scans including reduction of tube current and tube voltage as well as the use of novel
noise reduction techniques such as iterative reconstruction IR However the resultant radiation dose of
existing CTP scans is still significantly higher than that of a standard head CT scan The application of IR
techniques in CTP is very limited due to the high complexity and computational burden for processing multiple
CTP images that may impair clinical workflow The overarching goal of the present STTR project is to develop
and commercialize a novel CT imaging platform that reduces the radiation dose of existing CTP techniques by
without compromising imaging speed or quality This proprietary technology reduces the radiation dose
of CTP scans by controlling the X ray source to be on intermittently instead of continuously at pre specified
rotation angles i e programmed pulsed X ray The dynamic CTP image series can then be reconstructed
using algorithms that preserve high spatial and temporal resolutions as well as image quality comparable to
those of standard CTP scans During the proposed Phase project we plan to demonstrate a proof of concept
of our technology by further developing optimizing and evaluating the image reconstruction algorithm using
both phantom and clinical CTP data We will also collaborate with CT vendors to ensure the developed
technology has a realistic pathway to commercialization Relevance to Public Health
More than million CT scans are performed every year in the US estimated to cause cases of future
cancers This project will develop evaluate and commercialize a novel CT imaging platform that reduces the
radiation dose of existing CT perfusion techniques by without compromising imaging speed or quality

* Information listed above is at the time of submission. *

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