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Direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41MH115884-01
Agency Tracking Number: R41MH115884
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 101
Solicitation Number: PA16-303
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-01
Award End Date (Contract End Date): 2018-08-31
Small Business Information
El Cerrito, CA 94530-1757
United States
DUNS: 079831471
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (510) 334-2950
Business Contact
Phone: (510) 334-2950
Research Institution
ALBUQUERQUE, NM 87131-0001
United States

 Nonprofit College or University

Project Summary
ODMR Technologies Inc and Prof Victor Acostaandapos s group at University of New Mexico UNM are developing a
diamond chip platform capable of direct magnetic characterization of individual nanoparticles for optimized
diagnostic imaging Our team is a spinoff from academic collaborations in the emerging field of diamond
photonic sensors a field we helped create nearly a decade ago After years of refining this technology in the
lab we are ready to commercialize our most promising devices
Magnetic nanoparticle MNP research has seen a flurry of activity in recent years owing to potential
applications in catalysis data storage biosensing medical imaging including magnetic resonance imaging
MRI magnetic particle imaging and magnetic relaxation imaging MRX drug delivery and hyperthermia
treatment These applications would benefit from using MNPs with highly uniform composition size shape
and magnetic properties However MNP production is notoriously plagued by reproducibility problems
inaccurate specifications and a lack of common practices Tools for quantitative magnetic measurements of
individual nanoparticles are not commercially available Advanced characterization tools are often either
inaccessible due to cost and maintenance or simply do not exist If the cost accuracy versatility and
throughput of proposed instruments can be improved they could have a dramatic impact on MNP applications
Developing a diamond chip platform for high sensitivity parallel characterization of individual MNPs is the
focus of this proposal The magnetic hysteresis and relaxation properties of thousands of individual MNPs will
be simultaneously characterized using a magnetic microscope based on nitrogen vacancy NV color centers
doped near the surface of a diamond chip The magnetic measurements for each individual MNP will be
correlated with its composition and morphology as determined by high resolution transmission electron
microscopy Unlike existing techniques the proposed platform works at ambient conditions and offers high
throughput andgt individual particles per min
To date we have built a setup designed for imaging particles with nm core diameters In the proposed
research plan we will optimize the benchtop prototype for nm sized particles Our goal is to build a
benchtop magnetic imaging apparatus with T sensitivity in nm resolved pixels mT tuning
range and andgt frames per second Next we will characterize the magnetic dynamics of superparamagnetic
iron oxide nanoparticles SPIONs with nm diameter with a goal of improving their applicability in
biomedicine We will obtain hysteresis curves and magnetization decay curves with record throughput
Correlative TEM and magnetic images of numerous individual SPIONs will be obtained and may finally
unambiguously elucidate the relationship between SPION size shape magnetization relaxation and
hysteresis curve properties Project Narrative
The goal of the proposed research is to develop a new type of sensor for direct magnetic characterization of
individual nanoparticles at ambient conditions and with high throughput andgt individual particles per min
Our characterization tool may be used for refining the fabrication process of magnetic nanoparticles for
biomedical imaging diagnostics and therapeutics and may be the enabling technology that propels the field
toward clinical applications In the longer term the technology may be used for high throughput sorting of
individual nanoparticles based directly on their magnetic properties

* Information listed above is at the time of submission. *

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