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Wavefront guided customized soft contact lens for highly aberrated eyes

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R44EY025095-02
Agency Tracking Number: R44EY025095
Amount: $1,460,377.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N
Solicitation Number: PA14-071
Timeline
Solicitation Year: 2014
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-30
Award End Date (Contract End Date): 2019-08-31
Small Business Information
6 LANCASTER PKWY
Lancaster, NY 14086-9713
United States
DUNS: 079170538
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 CHARLES CREIGHTON
 (716) 937-9187
 charley@aldenoptical.com
Business Contact
 AARON KLEIN
Phone: (585) 734-6011
Email: amklein5555@gmail.com
Research Institution
N/A
Abstract

The ultimate goal of this Fast Track small business research project is to improve the vision of people who
have abnormal corneal conditions that substantially alter the corneal shape such as keratoconus and corneal
transplantPatients with abnormal corneal shapes have substantially larger magnitudes of both lower order
and higher order aberrations compared to normalsEven with optimal sphero cylindrical correctionthe
uncorrected residual higher order aberrations cause a clinically significant degradation in visual qualityCorrecting the higher order aberrations has been challenging due to both the inability to measure highly
aberrated eyes and to manufacture a contact lens with an irregularnon rotationally symmetricalsurface
profileThis research project is designed to address these current barriers by developing a commercial gradelarge dynamic range wavefront sensortogether with freeform machining technology to fabricate wavefrontguided
customized soft contact lensesIn Phasewe will demonstrate the feasibility of freeform machining
technology to create an irregularnon rotationally symmetricallens surface profile capable of correcting higher
order aberrationsPhaseAimand minimizing unpredictable translation and rotation of the lens on eye by
customizing the back surface of the lens matched to the irregular anterior surface of the corneaPhaseAimIn PhaseAimwe will develop a commercial grade large dynamic range wavefront sensor equipped
with user friendly software for wavefront analysis and contact lens designIn PhaseAimwe will evaluate
methods to maximize the visual benefit with the wavefront guided lens by minimizing the adverse impact of
residual lens movement on correction performanceThenin PhaseAimwe will compare the visual
outcomes with this customized soft contact lensCustomEyesto those with soft contact lenses designed to fit
keratoconic eyes but with conventional sphero cylindrical optics to determine the clinical feasibility and the true
visual benefit provided by the wavefront guided customized soft lens in keratoconus patients

* Information listed above is at the time of submission. *

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