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Design and Synthesis of Bio-inspired Macromolecules Containing Atomically Precise Catalytic Active Sites

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-SC0015741
Agency Tracking Number: 0000231600
Amount: $999,496.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: 09d
Solicitation Number: DE-FOA-0001646
Solicitation Year: 2017
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-07-31
Award End Date (Contract End Date): 2019-07-30
Small Business Information
200 Yellow Place
Rockledge, FL 32955-5327
United States
DUNS: 175302579
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Ted Amundsen
 (321) 631-3550
Business Contact
 Michael Rizzo
Phone: (321) 631-3550
Research Institution
 Temple University
 Christian Schafeister
3340 N. Broad Street Suite 427
Philadelphia, PA 19122-2585
United States

 (215) 204-7118
 Nonprofit College or University

High selectivity in chemical reactions is the key to reducing costs, energy consumption and emissions in chemical processing. More selective and active catalysts will reduce the need for recovering unreacted chemicals for recycle and removing byproducts. Reducing the burden on separation processes will greatly reduce the energy required for chemical production. We will design macromolecular catalysts that resemble clamshells to act as highly selective C-H activation catalysts. These macro molecules will create complex, chiral pockets to bind metal ions, react with oxidants or molecular oxygen and react selectively with C-H bonds in a variety of hydrocarbon compounds. In Phase I we demonstrated two synthetic approaches to macromolecules that display two metal binding sites and contain 8 and 24 stereocenters, respectively. The synthesis of these compounds demonstrates that molecules of the size needed to create binding pockets will be attainable in Phase II. We also performed a market study and found significant interest in chiral catalysts by potential customers. In Phase II we will refine the synthesis methods and evaluate the catalytic activity of these materials when exposed to a panel of substrates. This will confirm the production of desired products as well as observe off-target catalytic activity that could lead to new applications of these molecules. The commercial applications of these catalysts are immense and include pharmaceuticals, agrochemicals and personal care products. The public will benefit from lower cost goods as a result of more efficiently manufacturing processes. The public will also benefit from the reduced emissions of processes made more efficient by these catalysts.

* Information listed above is at the time of submission. *

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