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Diagnostic device for detecting biomarkers of early multiorgan injury in saliva

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-17-C-0189
Agency Tracking Number: A2-6803
Amount: $1,000,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHP16-006
Solicitation Number: 2016.1
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-25
Award End Date (Contract End Date): 2020-02-24
Small Business Information
4878 Ronson CT STE K
San Diego, CA 92111
United States
DUNS: 159070825
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Richard Baldwin
 Chief Scientist
 (858) 565-4227
Business Contact
 Steven Oldenburg
Phone: (858) 565-4227
Research Institution

Combat soldiers are exposed to vast numbers of dangerous chemicals with potentially adverse health outcomes. This SBIR proposal aims to develop a new class of saliva based diagnostic assays that will measure the bodys response to toxic chemical exposure with a panel of clinically validated biomarkers that are indicative of organ injury. The tests will leverage the proven functionality of lateral flow diagnostic devices with novel nanoparticles and extraction formats that have the potential to increase lateral flow assay sensitivity by up to 3 orders of magnitude over the current state of the art. The developed diagnostic will be rapid, inexpensive and accurate. A smart phone based reader compatible with equipment already carried by soldiers will quantify the signal from each of the channels of the multiplexed diagnostic and interpret the results.

* Information listed above is at the time of submission. *

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