You are here

Cell Phone-based Early Detection of Multi-Organ Injury Biomarkers in Saliva

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-17-C-0190
Agency Tracking Number: H2-0235
Amount: $999,998.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHP16-006
Solicitation Number: 16.1
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-25
Award End Date (Contract End Date): 2020-05-31
Small Business Information
2520 W. 237th Street
Torrance, CA 90505
United States
DUNS: 033449757
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Manal Beshay
 Principal Scientist
 (424) 262-6360
Business Contact
 Sandy Honda
Phone: (424) 263-6313
Research Institution

Rapid diagnosis in conflict areas is a growingmilitary need, as troops areexposed to chemical threats ( Testingfor biomarkers in saliva has recently shown great promisein diagnostics, prognostics, and treatmentefficacy follow-up. In addition to itsconveniencefor field sampling and rapid testing,saliva is a rich body fluid with a number of physiological markers. Intelligent Optical Systems (IOS), in collaboration with Dr.James deLemos of the University of Texas Southwestern Medical Center, Dr. Craig Miller and Dr.Jeffrey Ebersole of the University of Kentucky, CellmicLLC, and Alfa Scientific, proposes to develop a cell phone-based rapid diagnostic devicefor organ injury biomarkers in saliva. The PhaseI work has demonstrated therapid diagnostics principle of an organ-specific panel forcardiac and liver markers. In PhaseII, IOSwillexpand itscapability to include additional panels for brain and kidneyearly injury markers, and expand clinical validation testing of human saliva samples. IOS hasextensiveexpertise designing, fabricating, and validatingits lateral flow assays (LFA) for point ofcare(POC) applications. The proposed platform will support frequent onsitetesting of troops against organ injuries thatcould result from theirexposureto toxicchemicals.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government