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Portable Iron Screening System for Point-of-Care Iron Status Determination

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-17-C-0177
Agency Tracking Number: H2-0256
Amount: $999,904.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHP16-005
Solicitation Number: 2016.1
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-28
Award End Date (Contract End Date): 2020-02-27
Small Business Information
701 McMillian Way NW
Huntsville, AL 35806
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Jenna Rosano
 Senior Research Engineer
 (256) 726-4905
Business Contact
 Deborah Phipps
Phone: (256) 726-4884
Research Institution

Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia (IDA). Women undergoing basic military training are particularly susceptible to reduced and depleted iron stores. To-date, there are no point-of-care (POC) instruments for comprehensive, accurate determination of iron status. We propose to develop a novel POC iron screening system, which utilizes affinity-based sensors to rapidly and selectively measure serum markers and perform blood analysis on an integrated cartridge. The cartridge will be integrated into a complete system with user-friendly software, and capabilities of accessing Electronic Health Records (HER). In Phase I, we successfully demonstrated proof-of-concept of key technology elements including plasma separation and ferritin and soluble transferrin receptor (sTfR) detection at physiological levels. In Phase II, the sensor platform will be extended to include a comprehensive set of biomarkers for iron deficiency. The sensor elements will be optimized and integrated into a single cartridge for multiplex detection. At the conclusion of Phase II, a complete, validated, portable iron screening system will be ready for commercialization and transition, which will be actively pursued beyond Phase II.

* Information listed above is at the time of submission. *

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