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Engineered Strain for Bioconversion of Food Waste to Fuels

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-17-P-0060
Agency Tracking Number: A17A-011-0140
Amount: $150,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A17A-T011
Solicitation Number: 2017.0
Solicitation Year: 2017
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-06-23
Award End Date (Contract End Date): 2017-12-22
Small Business Information
1515 West 2200 South
Salt Lake City, UT 84119
United States
DUNS: 829431076
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Mukund Karanjikar
 (801) 557-5923
Business Contact
 Anant Samudra
Phone: (801) 953-1047
Research Institution
 William Marsh Rice University
 Aaron Parvis
6100 Main Street
Houston, TX 77005
United States

 (713) 348-4820
 Nonprofit College or University

The proposed strategy in this STTR proposal for bioconversion of food waste to butanol uses the well-described Clostridium acetobutylicum organism to convert the carbohydrate to the fuel molecule butanol. Based on our teams many years of work with butanol formation and genetic studies of the organism and the advancement of recently developed genetic methods, the team will develop a set of genetic tools that show proof of principle for demonstration of 5 or more native regulatory elements with differential responses that can be used as orthogonal controls of expression depending on environmental conditions or substances present. These differential controls will be related to the presence of various sugars, amino acids, or redox conditions. We will show their induction in cultures with promoter and regulator controlled expression of an easily detectable reporter. We will also demonstrate the use of these control systems to express other genes that will enhance pathways for feedstock utilization or improved metabolite distribution toward the product. These experiments will prepare a standard method and toolkit for manipulation of other microbes for improved use of food waste and convert a higher proportion to useful fuels and thus reduce waste costs while generating useful products for the military.

* Information listed above is at the time of submission. *

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