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Modeling of Polytonic Dose Response Relationships

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-17-C-0154
Agency Tracking Number: H16C-001-0060
Amount: $149,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHP16C-001
Solicitation Number: 2016.0
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-06-26
Award End Date (Contract End Date): 2018-01-25
Small Business Information
10 Lakeview Circle
Greenbelt, MD 20770
United States
DUNS: 080431694
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Raymond Peterson
 Managing Director
 (301) 318-5121
Business Contact
 Raymond Peterson
Phone: (301) 318-5121
Research Institution
 University of California, Davis
 David Rocke
1850 Research Park Drive Suite
Davis, MD 95618
United States

 (530) 752-6999
 Nonprofit College or University

Dose response relationships are fundamental to pharmacology and many other fields. Increasingly, scientists are encountering polytonic dose response relationships. These relationships are not well-characterized by linear and s-shaped models. Our team has extended the traditional 4 parameter logistic model by replacing the dose parameter with the quadratic function as an effective dose function. This approach visually fits the dose response data of Zhang better than the nonparametric method that Zhang proposes. Our phase I work plan is to fully characterize this approach, to apply it to a range of polytonic dose response relationships, and to prototype cloud software that makes the approach useful to others. The principle investigator of the team is David Rocke, Director of Biostatistics for the Clinical and Translational Science Center of the University of California, Davis. David has been recognized internationally for his work. Also participating as statistician from UC Davis is Blythe Durbin-Johnson, who has 70 publications. The project manager, from Granite Point Ventures, is Raymond Peterson. He has been principle investigator on $4.6 million in SBIR projects.

* Information listed above is at the time of submission. *

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