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Complex Crystalloid Resuscitative Fluid

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-18-C-0018
Agency Tracking Number: H172-009-0201
Amount: $148,800.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: DHA172-009
Solicitation Number: 2017.1
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-04-09
Award End Date (Contract End Date): 2018-11-08
Small Business Information
1000 S. Pointe Drive
Miami Beach, FL 33139
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 David Steed
 (412) 298-9819
Business Contact
 George Sing
Phone: (917) 882-8001
Research Institution

The published data has demonstrated that the currently available resuscitation fluids have detrimental effects on trauma outcomes.By addressing these deficiencies it is expected that the outcomes will improve. The crystalloid based resuscitation fluid in development by GanD Inc. has been designed to address all of the shortcomings of the currently available solutions.The solution, GND-001, is a crystalloid with a decreased chloride concentration to reduce hyperchloremic acidosis and buffered with acetate, which can be utilized as a Kreb cycle intermediate.The overall concept is to replace metabolic components consumed in response to trauma and hemorrhage.These components including amino acids, Kreb cycle intermediates, and micronutrients have been identified using metabolomic profiling of trauma patients.We have also include specific vitamins as the literature has shown that certain vitamins have potent anti-inflammatory effects, such as Vitamin E derivatives that have been investigated in acute radiation sickness.Additionally, the GND-001 will be calcium free to allow the co-administration of blood products with the fluid. We believe that GND-001 will improve outcomes following severe hemorrhage by replacing lost components and aid in the recovery at the cellular level.

* Information listed above is at the time of submission. *

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