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Human Performance Optimization

Award Information
Agency: Department of Defense
Branch: Special Operations Command
Contract: H9222218P0036
Agency Tracking Number: S17C-001-0016
Amount: $149,904.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: SOCOM17C-001
Solicitation Number: 2017.0
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-05-17
Award End Date (Contract End Date): 2018-11-19
Small Business Information
235 freeman apt 3
brookline, MA 02116
United States
DUNS: 080085661
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Noah Davidsohn
 (516) 473-1287
Business Contact
 Daniel Oliver
Phone: (916) 396-3714
Research Institution
 Jackson Laboratory
 Michael Walden
600 Main St
bar harbor, ME 04609
United States

 (207) 288-1461
 Domestic Nonprofit Research Organization

Special Operations Forces (SOF) are an integral aspect of the US military. SOF operators are among the most elite and highly qualified individuals in the U.S. military. As such, extraordinary physical and mental demands are placed upon them to excel in extreme environments for extended periods of time. This unrelenting cycle of combat deployments and intense pre-deployment training shortens the functional life of operators, a highly undesirable outcome. Rejuvenate Bio developed a gene therapy platform that identified genes that can increase the stress-resistance, health and lifespan of mice as well as mitigate three different age-related diseases (heart failure, diabetes and obesity). We believe that these novel gene therapies will also enhance performance due to their modulations of stress responses and metabolic energy pathways. As a first step toward developing therapies for humans, we propose to measure the effect of these gene therapies on endurance, speed of recovery, and resistance to muscle damage. Completion of this Phase I study will enable us to begin Phase II testing of these therapies ability to enhance performance in a large animal model (canines). Using aging as a model to discover performance enhancing genes will allow for increased performance now and far into the future.

* Information listed above is at the time of submission. *

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