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Reopening the Central Airway With Needle-Size Tentacle Manipulators

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL140709-01
Agency Tracking Number: R41HL140709
Amount: $224,598.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA16-303
Solicitation Year: 2016
Award Year: 2018
Award Start Date (Proposal Award Date): 2017-12-15
Award End Date (Contract End Date): 2019-11-30
Small Business Information
Nashville, TN 37205-3623
United States
DUNS: 080295493
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (615) 322-0193
Business Contact
Phone: (615) 322-0193
Research Institution
NASHVILLE, TN 37240-7749
United States

 Nonprofit College or University

Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments on a new hand held surgical instrument that provides dexterity at the tip of a rigid bronchoscopeThis approach is less invasive than traditional open
surgeryand will be safer than the current rigid bronchoscopic approachwhich lacks dexterity in port delivered
instrumentsOur new system will feature needle sized manipulators deployed through the bronchoscopeandapos s port
and will enable lateral tool motion for independent tissue manipulationlaser aimingand visualizationwhich we
hypothesize will make central airway obstruction surgery more accurate and ef cientClinical signi cance comes from the many patients affected by central airway obstructionoverper
year in the USA aloneas well as the severity for individual patientssince lack of an adequate airway is
fatalExisting surgical approaches are challenging because instruments deployed through bronchoscope ports
lack lateral dexterityand consequently complication rates are highof patients will have complications
including broken teethcervical spine injuryhemorrhageand even deathInnovation comes from using elastic interactions in curved tubes to create needle size manipulators that can
bend and elongateThis enables us to make manipulators small enough to pass through the port in a clinical
bronchoscope to provide tentacle like dexterity at its tipOur system will also be innovative because it will be
therst commercial robotic system designed for central airway surgeryand because it will be a small hand held
tool rather than a largecomplicated system in which the surgeon sits at a console remote from the patient and
teleoperates a large multi arm robot that surrounds the patientOur new hand held paradigm is advantageous
from both a work ow and cost perspectivebecause it is compact with dramatically fewer mechanical and electronic componentsand so has the potential to be an order of magnitude less expensive than the surgical robots
on the market todayOur approach in Aimis to create a hand held unit that clips onto the back of the bronchoscope and enables
the surgeon to control our proposed needle sizedtentacle like instrumentsAccomplishing this will require
hardware adaptations to an existing concentric tube actuation unit prototype developed in an academic laboratorytechnology that will be transferred to Virtuoso Surgical via this projectas well as the design and manufacturing
of tubes customized for the requirements of central airway obstruction surgeryIn Aimwe experimentally
validate the feasibility of removing central airway obstructions in anthropomorphic phantoms and an ex vivo
insuf ated porcine lung modelThe end result of this Phase I STTR project will be experimental validation of the
feasibility of resecting central airway tumors with our new hand held robot paradigmThis will set the stage for
the development of a sterilizablebiocompatible product in the context of a follow on Phase II project NarrativePublic Health Relevance
Central airway obstruction affects overpatients per year in the USA aloneand current surgical approaches are invasivewith approximatelyof patients suffering complications including neck injuryhemorrhageand even deathdue to lack of instrument dexterityWe propose to create new needle sizedtentacle like
instruments that will enable the surgeon to dexterously manipulate surgical tools in the central airway endoscopicallyThis system promises to increase the accuracy and ef ciency of surgery and thereby reduce complication
rates for patients with central airway obstructions

* Information listed above is at the time of submission. *

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