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Magnetic camera based on optical magnetometer for neuroscience research

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS108898-01
Agency Tracking Number: R41NS108898
Amount: $219,167.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 101
Solicitation Number: PAR15-090
Solicitation Year: 2015
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-01
Award End Date (Contract End Date): 2019-06-30
Small Business Information
Lafayette, CO 80026-1166
United States
DUNS: 080995606
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (703) 405-5018
Business Contact
Phone: (703) 405-5018
Research Institution
AURORA, CO 80045-2571
United States

 Nonprofit College or University

During Phase Iwe will test the feasibility of developing a magnetographic camera technology as a new tool in
neuroscience to facilitate the detailed analysis of electrical currents in diverse neuronal circuitsInstead of
photographic imagesthe camera will produce single shot images of the magnetic fields from in vivo samples
of interestsuch as a patch of the grey matter in the cerebral cortex or the dorsal hippocampusThe camera will
be based on the room temperature microfabricated optically pumped magnetometerOPMtechnology that
we have been developing during the past decadeOur stand alone singleOPMs have noise levels comparable
to the magnetometers based on superconducting technologybut we have not yet used OPMs to develop a multipixel cameraWe believe they can be used to build a camera with more than one megapixelsproviding high
spatial and temporal resolutionIn Aimwe will build a bench top proof of concept camera system operating
in a magnetically shielded roomThe OPM transduces each magnetic image into an optical image that is detected
by the CMOS detector atfps or greaterOur preliminary results have noise levels of andltfTHz for ampixel size and andltfTHz for ampixelIn Phase Iwe will improve the noise level of the detector by
a factor ofand will improve our detector design to reduce the currentmm gap between the sample and
detectorOur target Phase II goal is to reduce this gap tomIn Aimwe will evaluate the possibility of
using the camera in combination with an array of electrodes to analyze neuronal currents in a novel wayIn
neurophysiological studiesthe emphasis has been placed almost exclusively on analyzing the neuronal
interactions along the radial direction in the cortexperpendicular to the cortical surfaceThe physiology of the
horizontal connections parallel to the cortical surface has been much less emphasizedA high densityD array
of intracortical electrodes can in principle be used to determine both types of currents from the potential
measurementsHoweverthis is quite complex with large uncertaintyThe horizontal and radial circuitries can
be decomposed and separately analyzed by using the camera with an electrode array since the camera will
preferentially see the B fields produced by the horizontal circuitwhile the electrode array will see bothTogetherthese two types of circuitry can be analyzed to provide a better understanding of the cortical circuitWe will determine how well the Phase I camera can determine the horizontal circuitry in a simulation study and
in an in vitro intact isolated lissencephalic cerebellum of a turtle with the well known parallel fiber system in
the superficial molecular layer running parallel to the cortical surfaceIn Phase IIwe plan to develop a
completely self contained portable multi pixel camera with a magnetic shield inside the camera casing so that it
can be used anywhere without an extra shieldingIts usefulness will be evaluated for studying cortical and
hippocampal physiology in in vivo ratsSince the camera uses the MEMS technologyit can be eventually mass
produced economically for wide use in neuroscience Narrative
We will develop a novel type of magnetographic camera as a new tool in neurosciencecapable of providing
single shot images of electrical currents in neuronal circuits in vitro and in vivo with a millisecond time
resolutionIn Phase Iwe will test the feasibility of developing such a camera and evaluate its potential
applications in neuroscienceBy the end of Phase IIwe plan to produce a camera that can image neuronal
current distributions with a large array of pixelsi exhaving a spatial resolution as high asmatfpsbetter thanms resolutionand with a noise level of andltfTHz depending on pixel size

* Information listed above is at the time of submission. *

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