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System-independent quantitative cardiac CT perfusion

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL144271-01
Agency Tracking Number: R41HL144271
Amount: $224,240.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA17-303
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-08-01
Award End Date (Contract End Date): 2019-07-31
Small Business Information
Cleveland, OH 44143-2360
United States
DUNS: 192962061
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (216) 368-4099
Business Contact
Phone: (216) 373-1500
Research Institution
CLEVELAND, OH 44106-1712
United States

 Nonprofit College or University

System independent quantitative cardiac CT perfusion
BioInVisionIncand Case Western Reserve University researchers will develop software for quantitative analysis of cardiac CT perfusionCCTPcreating an important tool for evaluation of cardiovascular diseaseWith
this productcardiologists will be able to identify functional flow deficits in coronary artery territoriesWhen one
combines functional myocardial blood flowMBFwith coronary anatomy from computed tomography angiographyCTAit provides needed information on the physiologic significance of a stenosisThe CTA CCTP
combo could provide an ideal gateway exam for deciding whether to send a patient for percutaneous invasive
coronary angiography and potential interventione gstentingIn additionif flow is low and no stenosis is
presentit will suggest microvascular diseasea very prevalent ailment of growing concernespecially among
women and in diabetesCT compares favorably to all other non invasive cardiovascular imaging techniquesSPECTPETand MRIIt is available in many settingsincluding emergency departmentsIt provides both
MBF and reliable coronary anatomynot available in any other single modalityIt has excellent resolution enabling detection of endocardial perfusion deficitthought to be an early disease indicator that is impossible to
assess with SPECTCT is cheaper and has higher patient throughput than MRI or PETWith inclusion of MBFCT would have an excellent opportunity to disrupt the diagnostic pathway leading to percutaneous interventiona pathway now dominated by SPECT myocardial imagingwhich includes zero information about coronary
anatomyTo achieve reliableaccurate CT MBF measurementswe will invoke innovations to reduce beam
hardening and to make reliable estimates of flowCurrentlyCT perfusion is done on different CT machines
with manufacturersproprietary softwareusing algorithms that can give erroneous MBFsApplicable to any
commercial scannerour solution would harmonize measurements across acquisition systems providing trustworthystandardized measurements to cliniciansthereby improving management of cardiovascular patients Narrative
We will develop software to enable reliable evaluation of blood flow in heart tissue using CT imagingWith successour project could lead to an improved gateway examination that could reduce unnecessary invasive coronary angiographythereby reducing costspatient discomfortpatient riskand possibly unnecessary interventional therapies

* Information listed above is at the time of submission. *

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