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Development of fully integrated electrochemical device for detecting metals in biological fluids

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41ES029873-01
Agency Tracking Number: R41ES029873
Amount: $149,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIEHS
Solicitation Number: PA17-303
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-18
Award End Date (Contract End Date): 2019-08-31
Small Business Information
West Lafayette, IN 47906-1350
United States
DUNS: 040294803
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (205) 934-6103
Business Contact
Phone: (765) 476-9888
Research Institution
EAST LANSING, MI 48824-6206
United States

 Domestic Nonprofit Research Organization

Exposure to toxic levels of metals causes significant negative chronic health
problems in the exposed populationsDuring and after exposuremetals such as
manganeseleadnickelmercuryetcare present in biological fluidsA fully integrated
wearable device would enable real time monitoring of exposure levelsThis would
quickly alert those exposed to toxic concentrations of metals and mitigate the chronic
health problems caused by exposureBioanalytical Systems Incwill partner with
Fraunhofer USAIncCenter for Coatings and Diamond Technologies to develop
wearable device for the continuous monitoring of metals in biological fluids such as
sweatFraunhofer USAIncwill optimize the geometry of flexible boron doped diamond
electrodes with multiple working electrode for use with a multiplexer potentiostat
developed by Bioanalytical Systems IncThis device will be capable of detecting metals
at the concentration levels present in sweat through anodic and cathodic stripping
voltammetry and the wearable device will be a battery powered potentiostat capable of
Bluetooth communication and will be controlled by a cell phone or tablet Exposure to toxic levels of metal in the environment is a serious problem in many
workplace environmentssuch as miningmanufacturingand constructionand it is a
serious problem in the water and air nearby these locationsContinuous monitoring with
a wearable electrochemical device would improve understanding of how this affects
health and assist in mitigating exposure to toxic compoundsAn integrated device with
small flexible electrodes and a portable potentiostat that can be controlled by cell phone
would enable greatly improved monitoring of exposure levels

* Information listed above is at the time of submission. *

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