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A practical platform for in-home remote monitoring of cognitive-frailty

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AG061951-01
Agency Tracking Number: R41AG061951
Amount: $412,281.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PAR17-066
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-30
Award End Date (Contract End Date): 2019-08-31
Small Business Information
Cambridge, MA 02139-4654
United States
DUNS: 802270988
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (520) 626-7097
Business Contact
Phone: (888) 589-6213
Research Institution
HOUSTON, TX 77030-3411
United States

 Nonprofit College or University

AbstractCognitive frailtythe combined presence of physical frailty and cognitive impairmentis a strong and
independent predictor of cognitive declineThe International Association of Gerontology and Geriatrics and the
International Academy on Nutrition and Aging have recommended the use of cognitive frailty assessment to
track the progression of mild cognitive impairmentMCItowards dementiaAlzheimerandapos s diseaseADand loss
of independenceHoweverthere is no practical assessment tool for measuring cognitive frailty remotelysuch
as during a telehealth visitTelehealth video conferencing between patient and physician is growing in
popularityis increasingly accepted by healthcare payersand is especially attractive to older adults who may
not easily be able to travel to the clinicThereforethere is an unmet need for a software based solution for
remote assessment of cognitive frailty that can be integrated into existing telehealth systemsBased on a Direct Phase II SBIR grant award from the National Institute on AgingNIABioSensics LLC and
Baylor College of Medicine developed and commercialized Frailty MeterFMa novel wearable technology
for frailty assessmentFM works by quantifying frailty phenotypes including weaknessslownessrange ofmotionand exhaustion during asecond rapid repetitive elbow flexion extension taskWhen applied under
dual task conditionse gwhile performing a working memory taskFM can be used to assess cognitive
impairmentFM is well suited for use in a clinical environment because it is simple to administer andunlike
other measures of frailtyit does not require a walking testHoweverbecause FM is based on wearable
sensors there are technicallogisticaland cost associated challenges associated with its usage in a telehealth
settingTo address these limitationswe propose to develop a video based solution that uses image
processing algorithms to replicate the measurements taken by the wearable sensor in FMTo increase
market penetrationthis software solution will be provided as a plug in module that developers can easily
integrate into their video based telehealth platformregardless of whether the system runs on a tablet or a
custom developed telehealth kioskDuring Phase Iwe will develop image processing algorithms to enable real time motion tracking of the upper
arm and forearm during the FM taskFrom this data we will extract elbow rotational velocitythe measurement
needed for FM analysisand validate this measure against the sensor based deviceWe will also develop a
prototype tablet platform for video conferencing and remote cognitive frailty assessment that we can use in our
planned clinical studies during Phase IIThe clinical studies in Phase II will validate the effectiveness of this
platform for tracking longitudinal changes in cognitive motor impairment as a marker of dementia severity and
the progression from MCI toward AD Project Narrative
Cognitive frailtythe combined presence of physical frailty and cognitive impairmentis a strong and
independent predictor of cognitive decline over timeHoweveravailable screening tools are either unable to
monitor cognitive frailty or are impractical for clinical useparticularly in a telehealth settingThis application
proposes a practical and easy to use platform for in home remote monitoring of cognitive frailty and its subtle
changes over time based on a simple and clinically validated dual task elbow flexion extension test

* Information listed above is at the time of submission. *

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