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A novel RF coil and incubator for reducing acoustic noise in neonatal MRI

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HD097879-01
Agency Tracking Number: R41HD097879
Amount: $150,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NICHD
Solicitation Number: PA18-575
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-09-20
Award End Date (Contract End Date): 2019-03-31
Small Business Information
Cincinnati, OH 45203
United States
DUNS: 081127079
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (518) 387-7294
Business Contact
Phone: (513) 257-8902
Research Institution
CINCINNATI, OH 45229-3039
United States

 Domestic Nonprofit Research Organization

In this Phase I Small Business Technology TransferSTTRprojecta team of researchers at Cincinnati
Childrenandapos s Hospital Medical CenterCCHMCwill work with the engineering team at NeoViewIncto design
and build novel body coil and incubator prototypes for aTesla Neonatal Intensive Care UnitNICUMRI
systemThese components will play a central role in NeoViewandapos s neonatal MRI product which will for the first
time bring a fully featured high field MRI into the NICUThe novel body coil replaces the hard structural
components and hollow air spaces used in existing body coil designs with layers of Mass Loaded VinylMLVsupported by a rigid internal skeletonIn effectthe RF coil becomes a large cylindricalpillowplaced in the
bore of the magnetIn a prototypeTesla NICU MRI scanner at CCHMC this concept has been shown to
reduce the acoustic noise generated by the scanner bydBA with no impact on MR scanner protocols or
image qualityPreliminary tests have shown that a hard shell incubator placed inside the quiet coil reduces the
acoustic noise exposure for the patient by an additionaldBAThe reduction in a neonateandapos s acoustic noise
exposure afforded by NeoViewandapos s small magnetthe quiet coiland incubator is expected to be approximatelydBAThis dramatic decrease in noise has the potential to enable MRI neonatal scanning without the need
for hearing protectionThe team of CCHMC researchers and NeoView engineers will work together to first
evaluate the MR properties of MLV in a conventional whole bodyT MRI systemAcm high pass birdcage
coil will then be designed using electromagnetic simulations and built using layers of MLVImage quality and
acoustic attenuation evaluations will be carried out in both NICU and whole body MRI systemsA mock
incubator will also be constructed for evaluationThis mock incubator will have all the internal components
needed to support a neonate during scanning to create a realistic platform for evaluating acoustic noisebut
will not include subsystems for thermal and humidity managementThe impact of design choices for the
incubator walls and access ports on the ingress of acoustic noise will be evaluatedAt the end of this Phase I
projecta prototype coil and incubator will have been constructed and optimal design elements and critical
design requirements for product versions of the coil and incubator will be identifiedSuccessful completion of
this Phase I project will place the research team in an excellent position to develop product quiet coils and
incubators in Phase IIOnce Phase I and II are fully realizedMR scanning of non sedatedswaddled sleeping
infants will become possible without inducing physiologic stressand without the need to rely on hearing
protectionIntegrating these elements will advance MRI technology for neonatesimprove the clinical care of
premature babiesand enable new research metrics for studying early human developmentFurthermorewe
believe that the technical innovations in this projectalthough targeted at neonatal imagingwill also prove
useful in conventional adult sized MR scannersThe quiet RF coil approach in particular holds promise for
substantial reduction of acoustic noise without any impact on imaging protocols or performance PROJECT NARRATIVEThis project will develop new technology that will substantially reduce the acoustic noise
experienced by premature babies undergoing Magnetic Resonance ImagingThe ability to scan a sleeping
premature baby without hearing protection minimizes physiological stress and is expected to reduce the
incidence of motion induced artifactsWith the success of this projecta neonateandapos s small size will no longer
put him her at a disadvantage when it comes to MRbut instead will enable MR imaging beyond what is
possible in an adult scanner

* Information listed above is at the time of submission. *

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