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Reactor for Insect Cell Culture

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R42GM128484-01
Agency Tracking Number: R42GM128484
Amount: $334,239.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 300
Solicitation Number: PA18-591
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-05-01
Award End Date (Contract End Date): 2018-10-31
Small Business Information
Chapel Hill, NC 27599-0001
United States
DUNS: 078778864
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (919) 977-1083
Business Contact
Phone: (919) 302-6489
Research Institution
104 Airport Drive, Suite 2200
CHAPEL HILL, NC 27599-0001
United States

 Nonprofit College or University

This fast track STTR application proposes to synthesize structurally defined heparan sulfate and
chondroitin sulfate oligosaccharides for biological researchGlycan Therapeutics is a biotech
company specializing in synthesizing sulfated carbohydrates using innovative enzyme based
methodsThis proposal is focused on the synthesis of large authentic oligosaccharides in the
size range ofmers tomersas well as ultra large click oligosaccharides in the size range
ofsaccharide residue longA highly experienced research teamincluding DrYongmei XuUniversity of North CarolinaDrRobert LinhardtRensselaer Polytechnic InstituteDrJian
LiuUniversity of North Carolinaand DrVijay PagadalaGlycan Therapeuticswill carry out
the studyHeparan sulfate and chondroitin sulfate are members of the glycosaminoglycan
family present in large quantities on mammalian cell surfaces and in the extracellular matrixdisplaying a wide range of biological functionsThis proposal is designed to serve two
purposesito develop a reliable and cost effective method to synthesize structurally defined
heparan sulfate and chondroitin sulfate oligosaccharides and structurally controlled
polysaccharides to support glycoscience researchandiito simplify this technology to allow
nonglycoscientists to utilize this technology in a standard biochemistry laboratory settingWe
anticipate that this proposal will provide valuable technical advances to glycoscience researchThree specific aims are proposedAimis to synthesize a library of structurally defined
heparan sulfate oligosaccharides with a size of up to hexadecasaccharidesmersAimis
to develop novel chemoenzymatic methods to synthesize chondroitin sulfate oligosaccharidesAimis to prepare structurally controlled click heparan sulfates and chondroitin sulfate
oligosaccharides The purpose of this supplementary application is to request funding to purchase a
bioreactor systemThis instrument will be utilized to grow insect cells to produce both
heparan sulfate and chondroitin sulfate biosynthetic enzymes for the enzymatic
synthesis of both heparan sulfate and chondroitin sulfate oligosaccharidesThe new
bioreactor will increase our enzyme production capability byfoldallowing us to
complete the proposed synthesis

* Information listed above is at the time of submission. *

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