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A novel wearable platform to assess cognitive-motor performance

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AG058295-01A1
Agency Tracking Number: R41AG058295
Amount: $402,769.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PAS17-065
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-04-15
Award End Date (Contract End Date): 2020-03-31
Small Business Information
165 PLEASANT ST APT 302
Cambridge, MA 02139-4654
United States
DUNS: 802270988
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BIJAN NAJAFI
 (520) 626-7097
 bnajafi@surgery.arizona.edu
Business Contact
 NEDA MOVAGHAR
Phone: (888) 589-6213
Email: neda.movaghar@biosensics.com
Research Institution
 BAYLOR COLLEGE OF MEDICINE
 
1 BAYLOR PLAZA
HOUSTON, TX 77030-3411
United States

 Nonprofit College or University
Abstract

ABSTRACT
The recent shift in Alzheimer s diseaseADclinical research from clinical diagnosis toward the goal of
developing neuroprotective therapies has highlighted the need for a robust and rapidly administered cognitive
assessment tool capable of identifying individuals in the earliest stages of cognitive decline and measuring
subtle changes in cognitive motor performance over timeIn this contextphysical frailty together with
cognitive impairmentknown ascognitive frailtyis shown to be a strong and independent predictor of
cognitive decline over timeThe International Association of Gerontology and Geriatricsas well as The
International Academy on Nutrition and Aging have recommended the use of cognitive frailty measurement for
determining pathways of MCI progression toward dementia ADand loss of independenceWe have recently developed a novel cognitive frailty measurement tool that is based on a combination of a
wearable sensor attached to patient s shin and virtual reality softwareThe assessment performed using this
platform is the Instrumented Trail Making Task or iTMTThis innovative tool for objective and simultaneous
assessment of both motor and cognitive performance is used to examine the ability of the patient to execute a
trail making task in a virtual environmentThe assessment is based on measuring the execution time and user
performance during multiple tasks that involve visual searchscanningspeed of processingmental flexibilityand executive functionIn performing each taskmotor performance is quantified by measuring ankle velocity
and cognitive performance is quantified by assessing motor planning errorworking memoryand time needed
to complete the taskIn our pilot studywhich was recently published in Gerontologywe demonstrated that
iTMT can be used to assess cognitive motor performance and identify aMCI and AD in older adultsFurthermorewe have demonstrated the ability of iTMT to determine frailty statusThe iTMT could be used as
an alternative test to the dual task walking test to assess and quantify cognitive frailty in older adultsThe
unique benefits of the proposed platform include objectivitylow costtime savingsmultifaceted assessmentand being easy to useThis STTR Phase I study aims to transfer this innovative and patented technology from Baylor College of
Medicine to BioSensics LLC for further developmentclinical testingand commercializationBioSensics is a
privately held biomedical firm specialized in wearable technologies for healthcarewith a proven record of
rapidly transitioning governmental research funding into commercialized medical devices and technologiesThe iTMT product proposed here will be added to the current line of point of care assessment tools
commercialized by BioSensicswhich includes devices for gait and fall riskLEGSysbalanceBalanSensand FrailtyFrailty MeterProject Narrative
Recently proposed National Institute of AgingNIAand Alzheimerandapos s AssociationAAguidelines for the
diagnosis of Alzheimer s diseaseADrecognize the need to identify mild cognitive impairmentMCIand its
progression toward ADWhile cognitive impairment can be identified using pencil and paper based screening
toolsthese assessment tools are semi objectiveand time consumingand are often insensitive to determine
physical frailtywhich is known to be a predictor of further cognitive decline overtime and acceleration toward
dementia or ADThis grant application proposes designing and commercializing a low costobjectivetimeefficientand easy to apply instrumented trail making test systemiTMTto identify and track cognitive frailtyregardless of settingpatient education leveland examiner experience

* Information listed above is at the time of submission. *

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