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Technologies to Target Circadian Rhythm Disruption in PTSD

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-18-C-0070
Agency Tracking Number: A2-6769
Amount: $999,964.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: A16A-T014
Solicitation Number: 16.A
Solicitation Year: 2016
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-01-18
Award End Date (Contract End Date): 2019-01-18
Small Business Information
8445 Camino Santa Fe Suite 205
San Diego, CA 92121
United States
DUNS: 963381699
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Yu M Chi
 (469) 951-2227
Business Contact
 Michael Elconin
Phone: (619) 302-8686
Research Institution
 University of California, San Diego
 Dr. Julie Onton Dr. Julie Onton
9500 Gilman Drive
La Jolla, CA 92093
United States

 (858) 336-2704
 Nonprofit College or University

This STTR project will develop a wearable sensor suite for accurate assessment of circadian and sleep rhythms with the goal to identify abnormalities in PTSD patients and enable personalized therapy to help restore their normal functional and quality of life. Phase I has already demonstrated proof-of-principle hardware. The primary Phase II objective is to successfully carry out a human subjects study, at the San Diego VA, that samples circadian-related biochemical rhythms (cortisol, melatonin, neurotransmitter levels) with simultaneously acquired physiological sensor data (EEG, GSR, temperature, PPG/HR/HRV/SpO2, motion and ambient light/sound) to determine correlates between circadian activity and physiological measurements as well as abnormalities that are associated with PTSD. Supporting the study, our second Phase II objective is to continue advancing the Phase I hardware prototype into a pre-production model that meets the signal quality, wearability and durability requirements for multi-day acquisition. This sets the stage for subsequent efforts to conduct expanded studies, develop automated analysis algorithms, and clinical intervention protocols with the ultimate goal of a closed-loop PTSD diagnosis and intervention product.

* Information listed above is at the time of submission. *

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