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Fast Parameter Identification for Personalized Pharmacokinetics

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-18-C-0013
Agency Tracking Number: H17B-003-0049
Amount: $149,991.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHP17B-003
Solicitation Number: 17.B
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-04-09
Award End Date (Contract End Date): 2019-01-08
Small Business Information
221 River St 9th Floor
Hoboken, NJ 07030
United States
DUNS: 078572678
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Behnood Gholami
 CEO
 (347) 774-1617
 bgholami@aretexeng.com
Business Contact
 Behnood Gholami
Phone: (678) 886-6400
Email: bgholami@aretexeng.com
Research Institution
 University of Colorado Boulder
 Jennifer Archuleta Jennifer Archuleta
 
430 UCB Array
Boulder, CO 80309
United States

 (303) 492-7274
 Nonprofit college or university
Abstract

Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics),amodel for drug dosingcan begenerated.We proposeto develop acomputational frameworkfor system identification of pharmacokineticmodels,where we will usecompartmental dynamical systemsasageneral frameworkto model pharmacokinetics. A constrained optimization problem is formulated to find optimal parameters of thecompartmental model. A GPU-based numerical solver will be used to solvetheconstrained optimization problem.

* Information listed above is at the time of submission. *

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