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Functionalized, Therapeutic-Loaded Liposomes for the Acute Treatment of TBI

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH18C0352
Agency Tracking Number: H18A-001-0004
Amount: $149,998.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHA18A-001
Solicitation Number: 2018.0
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-06-11
Award End Date (Contract End Date): 2019-01-10
Small Business Information
301 1st Street SW
Roanoke, VA 24011
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Dr. Yang Xu
 (434) 483-4232
Business Contact
 Ms. Maggie Hudson
Phone: (434) 483-4254
Research Institution
 Virginia Polytechnic Institute and
 Linda Bucy
300 Turner Street NW Array
Blacksbur, VA 24061
United States

 (540) 231-5281
 Nonprofit College or University

Traumatic brain injury is a common problem in both the military and civilian communities, but current treatment protocols are focused on managing symptoms and fail to prevent significant long-term repercussions. In the proposed program, Luna will demonstrate the feasibility of a liposome-based therapeutic delivery system capable of delivering hydrophilic and hydrophobic therapeutics to the traumatically injured brain. An intranasal formulation will be developed to simplify administration and enable delivery within minutes to hours of injury, effectively minimizing the onset of secondary inflammatory responses that may be more damaging than the initial injury itself. In Phase I, Luna will demonstrate the feasibility of this delivery system using in vitro models, and in Phase II will demonstrate the functionality of these functionalized liposomes in in vivo TBI models.

* Information listed above is at the time of submission. *

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