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Brain Targeting Nanoparticle for Drug Delivery in Traumatic Brain Injury

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH18C0355
Agency Tracking Number: H18A-001-0019
Amount: $149,949.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHA18A-001
Solicitation Number: 2018.0
Timeline
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-06-11
Award End Date (Contract End Date): 2019-01-10
Small Business Information
12156 Parklawn Drive
North Bethesda, MD 20852
United States
DUNS: 809594661
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Xingguo Cheng, Ph.D.
 (210) 522-6354
 xingguo.cheng@swri.org
Business Contact
 Irving Weinberg
Phone: (301) 346-7944
Email: inweinberg@gmail.com
Research Institution
 Southwest Research Institute
 Bryce DeWispelare
 
6220 Culebra Rd. Array
San Antonio, MD 78238
United States

 (210) 522-5815
 Domestic nonprofit research organization
Abstract

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as control nanoparticles. The completion of this project and subsequent Phase II and III may lead to one or more highly effective (several orders of magnitude higher than conventional nanoparticles), highly targeted drug products which can be used for treatment of TBI and other Central Nerve System (CNS) diseases for both the Military and civilians.

* Information listed above is at the time of submission. *

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