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Developing Software for Pharmacodynamics and Bioassay Studies
Title: Professor of Statistics and Biostatistics
Phone: (202) 994-7844
Email: hliang@email.gwu.edu
Phone: (703) 348-8284
Email: larry.liu@tconnex.com
Contact: Rebekka Egger Rebekka Egger
Address:
Phone: (202) 994-7322
Type: Nonprofit College or University
Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further be used to obtain various important parameters such as IC50, EC50, ED50,LD50, Km, Vmax,and AUC. The tool can be used for hormesis doseresponsecurves. In toxicology, hormesis isaspecial doseresponsefeaturecharacterized by low dose stimulation and high doseinhibition.Furthermore, thetool can model U-shaped doseresponserelationships frequently observed in toxicologyand epidemiology studies
* Information listed above is at the time of submission. *