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Developing Software for Pharmacodynamics and Bioassay Studies

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH18C0152
Agency Tracking Number: H2-0307
Amount: $499,999.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: DHP16C-001
Solicitation Number: 16.C
Timeline
Solicitation Year: 2016
Award Year: 2019
Award Start Date (Proposal Award Date): 2018-10-01
Award End Date (Contract End Date): 2021-02-23
Small Business Information
7926 Jones Branch Drive, Suite 560
mclean, VA 22102
United States
DUNS: 001899546
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Hua Liang
 Professor of Statistics and Biostatistics
 (202) 994-7844
 hliang@email.gwu.edu
Business Contact
 Larry Liu
Phone: (703) 348-8284
Email: larry.liu@tconnex.com
Research Institution
 George Washington Universtiy
 Rebekka Egger Rebekka Egger
 
2121 I Street N.W. Suite 601
Washington DC, VA 20052
United States

 (202) 994-7322
 Nonprofit college or university
Abstract

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further be used to obtain various important parameters such as IC50, EC50, ED50,LD50, Km, Vmax,and AUC. The tool can be used for hormesis doseresponsecurves. In toxicology, hormesis isaspecial doseresponsefeaturecharacterized by low dose stimulation and high doseinhibition.Furthermore, thetool can model U-shaped doseresponserelationships frequently observed in toxicologyand epidemiology studies

* Information listed above is at the time of submission. *

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