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A point of care test for TB antibiotic concentration in blood

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N93019C00020
Agency Tracking Number: N43AI190020
Amount: $300,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
4878 Ronson CT STE K
SAN DIEGO, CA 92111-1806
United States
DUNS: 159070825
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Richard Baldwin
 (858) 349-5094
Business Contact
 Richard Baldwin
Phone: (858) 349-5094
Research Institution

TuberculosisTBis one of the topcauses of death worldwideTB treatments include combinations of multiple antibiotics and dosage levels over a long period of timeOften the dose must be adjustedLow antibiotic blood concentrations may cause slow responseprolonged infection or treatment failureand the TB strain may acquire drug resistancetoo high and toxicity may be an issueCurrent technologies for measuring blood antibiotic concentrations are slowexpensiveand require sophisticated instrumentspreventing the use of therapeutic drug monitoring in clinical practiceIn this proposal we describe the development of a point of care quantitative multiplexed lateral flow assay to measure the serum concentrations of key front line tuberculosis antibioticsThe assay will take a fingerstick blood sample and provide a readout of the serum concentration of multiple TB drugs within fifteen minutes at low costThe assay will utilize novel plasmonic particles with ultrahigh optical density as the generator of the visible signal to increase both the sensitivity and the dynamic range of the testThe assay will be first developed to detect and quantify blood concentration of Isoniazid and Rifampinand later extended to Pyrazinamide

* Information listed above is at the time of submission. *

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