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Development of a Prophylactic Onchocerciasis Vaccine

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N93019C00028
Agency Tracking Number: N44AI190028
Amount: $2,961,685.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1616 Eastlake Ave E Ste 550
SEATTLE, WA 98102-3788
United States
DUNS: 148051621
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Darrick Carter
 (206) 714-2724
 darrick.carter@pailifesciences.com
Business Contact
 Darrick Carter
Phone: (206) 714-2724
Email: darrick.carter@pailifesciences.com
Research Institution
N/A
Abstract

Humanriver blindnessis caused by a filarial parasite and is a serious neglected tropical disease contributing to blindnessskin diseaseand chronic disability in the developing worldEstimates from the Global Burden of Disease Studyindicate thatmillion cases of onchocerciasisleading tomillion cases of vision impairmentoccur worldwide every yearThe goal of this project is to develop a safe and effective vaccine to protect vulnerable populations in endemic areasThe vaccine will work by generating anti parasite immune responses which can reduce the burden of disease and interrupt the parasitic life cycle by eliminating both adult worms and microfilariaeThusit will contribute to reduction in transmission rates and will prevent recurrent diseaseIn our phaseresearchwe met both objectives byselecting and producing an optimal vaccine compositionanddemonstrating the efficacy of our candidates protecting against diseaseIn phasewe intend to translate our development efforts towards field deployment byproducing cGMP proteintesting its ability to protect animalsdemonstrating the vaccine is safe and effective in animal studiesand moving towards human clinical trials by having a pre IND meeting with the FDA

* Information listed above is at the time of submission. *

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