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TOPIC 396 - IMAGING FOR CANCER IMMUNOTHERAPIES-MOONSHOT

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91019C00014
Agency Tracking Number: N43CA190014
Amount: $299,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1507 Chambers Rd
COLUMBUS, OH 43212-1568
United States
DUNS: 153655340
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Arfaan Rampersaud
 (614) 302-0259
 arfaan@columbusnanoworks.com
Business Contact
 Arfaan Rampersaud
Phone: (614) 302-0259
Email: arfaan@columbusnanoworks.com
Research Institution
N/A
Abstract

In vivo imaging of cells labeled with fluorescent nanodiamondsFNDsis a new way of monitoring immune cells during cancer immunotherapyFNDs are non toxicinfinitely photostable nanomaterials that are easily conjugated with antibodiesand emit fluorescence in the near infrared spectral regionIn this Phase I SBIRwe will use a murine melanoma model and outline a plan to use FNDs for imaging immunosupressive cell populations as they enter the tumor microenvironment and peripheral tissues during immunotherapyIn Objectivewe will conjugatenm FNDs with antibodies that recognize tumor associated macrophagesTAMmyeloid derived suppressor cellsMDSCand regulatory T cellsT regIn Objectivewe will prepare TAMMDSC and T reg cells and characterize them by flow cytometry using commercial fluorescent antibodiesThe TAMMDSC and T reg will then be used to validate our antibody FND conjugatesIn Objectivewe will prepare FND labeled TAMMDSC and T reg cells ex vivo and fluorescently track these cell populations in melanoma bearing mice receiving placebo or mouse anti PD Lantibodyprogrammed death ligandinhibitorWe will also perform parallel studies where we image antibody FND conjugates that are directly injected through the tail veinOur results will provide tools for predicting the response to immunotherapy

* Information listed above is at the time of submission. *

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